Clmp CXADR-like membrane protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clmpprovided by RGD
Official Full Name: CXADR-like membrane proteinprovided by RGD
Primary source: RGD:708569
See related: EnsemblRapid:ENSRNOG00000053239 AllianceGenome:RGD:708569
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ACAM; Asam; Ol16
Summary: Predicted to be involved in digestive tract development and postsynaptic modulation of chemical synaptic transmission. Predicted to be located in bicellular tight junction and cytoplasmic microtubule. Predicted to be active in postsynaptic membrane. Human ortholog(s) of this gene implicated in short bowel syndrome. Orthologous to human CLMP (CXADR like membrane protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 142.1), Heart (RPKM 68.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (49957639..50065959)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (41060527..41168841)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (44846685..44975460)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced expression of coxsackievirus and adenovirus receptor in lipopolysaccharide-induced inflammatory macrophages is through TRIF-dependent innate immunity pathway.
Title: Enhanced expression of coxsackievirus and adenovirus receptor in lipopolysaccharide-induced inflammatory macrophages is through TRIF-dependent innate immunity pathway.
Data suggest that expression of Clmp in ovary during ovulation can be up-regulated by chorionic gonadotrophin; human chorionic gonadotrophin, a fertility agent, was used in these studies. Up-regulation of Clmp in ovary may be important in cell adhesion events during ovulation and luteal formation such as maintaining the structure and communication of ovarian follicular and luteal cells.
Title: CXADR-like membrane protein (CLMP) in the rat ovary: stimulation by human chorionic gonadotrophin during the periovulatory period.
We identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker in Xenopus) gene family, which may be the critical adhesion molecule in adipocyte differentiation and development of obesity.
Title: Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140450 (e-PCR)
- UniSTS:222525

BE105387 (e-PCR)
- UniSTS:245821

D8Mit13 (e-PCR), detects polymorphism
- UniSTS:240454

AU049061 (e-PCR)
- UniSTS:145509

BF389136 (e-PCR)
- UniSTS:245385

AW557819 (e-PCR)
- UniSTS:179877

RH139594 (e-PCR)
- UniSTS:221678

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in digestive tract development	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CXADR-like membrane protein

Names: CAR-like membrane protein; adipocyte adhesion molecule; adipocyte-specific adhesion molecule; coxsackie- and adenovirus receptor-like membrane protein; visceral adipose tissue-specific transmembrane protein OL-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173154.2 → NP_775177.1 CXADR-like membrane protein precursor

See identical proteins and their annotated locations for NP_775177.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q8K1G0

UniProtKB/TrEMBL

A0A8I5ZS82, A6J3Q7

Related

ENSRNOP00000069336.1, ENSRNOT00000080288.3

Conserved Domains (3) summary

smart00410
Location:143 → 224

IG_like; Immunoglobulin like

pfam07686
Location:28 → 128

V-set; Immunoglobulin V-set domain

pfam13895
Location:137 → 224

Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

49957639..50065959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080937.2 → XP_038936865.1 CXADR-like membrane protein isoform X1

Conserved Domains (2) summary

smart00409
Location:143 → 224

IG; Immunoglobulin

cd20960
Location:12 → 126

IgV_CAR_like; Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins