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    Coro2a coronin 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313235, updated on 9-Dec-2024

    Summary

    Official Symbol
    Coro2aprovided by RGD
    Official Full Name
    coronin 2Aprovided by RGD
    Primary source
    RGD:1309719
    See related
    EnsemblRapid:ENSRNOG00000008901 AllianceGenome:RGD:1309719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be located in brush border. Predicted to be part of transcription repressor complex. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 42.1), Brain (RPKM 33.0) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Coro2a in Genome Data Viewer
    Location:
    5q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65623820..65677483, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60825630..60881917, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (62154526..62210797, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate synthase Neighboring gene tripartite motif-containing 14 Neighboring gene uncharacterized LOC108350963 Neighboring gene uncharacterized LOC108350962 Neighboring gene TBC1 domain family, member 2 Neighboring gene uncharacterized LOC120102869

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    coronin-2A
    Names
    coronin, actin binding protein 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012101.2NP_001012101.2  coronin-2A

      Status: VALIDATED

      Source sequence(s)
      BC079209, JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2QC56, A6IJC5
      Related
      ENSRNOP00000011787.7, ENSRNOT00000011787.9
      Conserved Domains (6) summary
      PTZ00421
      Location:29536
      PTZ00421; coronin; Provisional
      pfam08953
      Location:2784
      DUF1899; Domain of unknown function (DUF1899)
      pfam13863
      Location:496534
      DUF4200; Domain of unknown function (DUF4200)
      pfam16300
      Location:369411
      WD40_4; Type of WD40 repeat
      sd00039
      Location:5999
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:98327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      65623820..65677483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238058.5XP_006238120.1  coronin-2A isoform X2

      See identical proteins and their annotated locations for XP_006238120.1

      UniProtKB/TrEMBL
      A6IJC5, F1LSP7, Q6AY36
      Conserved Domains (2) summary
      sd00039
      Location:4080
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_063287629.1XP_063143699.1  coronin-2A isoform X2

      UniProtKB/TrEMBL
      A6IJC5, F1LSP7, Q6AY36
    3. XM_017593364.3XP_017448853.1  coronin-2A isoform X1

      UniProtKB/TrEMBL
      A0A0G2QC56, A6IJC5
      Conserved Domains (6) summary
      PTZ00421
      Location:29536
      PTZ00421; coronin; Provisional
      pfam08953
      Location:2784
      DUF1899; Domain of unknown function (DUF1899)
      pfam13863
      Location:496534
      DUF4200; Domain of unknown function (DUF4200)
      pfam16300
      Location:369411
      WD40_4; Type of WD40 repeat
      sd00039
      Location:5999
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:98327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_039109864.2XP_038965792.1  coronin-2A isoform X2

      UniProtKB/TrEMBL
      A6IJC5, F1LSP7, Q6AY36
      Conserved Domains (2) summary
      sd00039
      Location:4080
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...