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    Cibar1 CBY1 interacting BAR domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cibar1provided by RGD
    Official Full Name
    CBY1 interacting BAR domain containing 1provided by RGD
    Primary source
    RGD:1310681
    See related
    EnsemblRapid:ENSRNOG00000016338 AllianceGenome:RGD:1310681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam92a; Fam92a1; RGD1310681
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including inner mitochondrial membrane organization; membrane tubulation; and positive regulation of smoothened signaling pathway. Predicted to be located in several cellular components, including centriole; ciliary base; and mitochondrial crista. Predicted to be active in ciliary basal body and ciliary transition zone. Orthologous to human CIBAR1 (CBY1 interacting BAR domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 189.1), Brain (RPKM 135.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cibar1 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (30411325..30429770, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (25613993..25632440, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (25732457..25750953, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 12B-A-like Neighboring gene transmembrane protein 67 Neighboring gene RNA binding motif protein 12B Neighboring gene uncharacterized LOC120102833 Neighboring gene triple QxxK/R motif containing Neighboring gene transfer RNA threonine (anticodon AGU) 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of two novel variants of the DUF1208 protein FAM92A1. Ruan XZ, et al. Mol Cells, 2007 Jun 30. PMID 17646714
    2. FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function. Wang L, et al. J Cell Biol, 2019 Jan 7. PMID 30404948, Free PMC Article
    3. FAM92A Underlies Nonsyndromic Postaxial Polydactyly in Humans and an Abnormal Limb and Digit Skeletal Phenotype in Mice. Schrauwen I, et al. J Bone Miner Res, 2019 Feb. PMID 30395363, Free PMC Article
    4. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. Li FQ, et al. Mol Cell Biol, 2016 Nov 1. PMID 27528616, Free PMC Article
    5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner mitochondrial membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner mitochondrial membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CBY1 interacting BAR domain containing 1; CBY1-interacting BAR domain-containing protein 1
    Names
    family with sequence similarity 92 member A
    family with sequence similarity 92, member A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431154.1 → NP_001418083.1  CBY1 interacting BAR domain containing 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6II83

    2. NM_001431155.1 → NP_001418084.1  CBY1 interacting BAR domain containing 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NM_001431156.1 → NP_001418085.1  CBY1 interacting BAR domain containing 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      30411325..30429770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261262.1 → XP_063117332.1  CBY1-interacting BAR domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZV0
      Related
      ENSRNOP00000084687.2, ENSRNOT00000115551.2

    2. XM_063261263.1 → XP_063117333.1  CBY1-interacting BAR domain-containing protein 1 isoform X2

      Related
      ENSRNOP00000022249.8, ENSRNOT00000022249.9

    3. XM_063261265.1 → XP_063117335.1  CBY1-interacting BAR domain-containing protein 1 isoform X4

    4. XM_002729463.7 → XP_002729509.2  CBY1-interacting BAR domain-containing protein 1 isoform X6

    5. XM_063261266.1 → XP_063117336.1  CBY1-interacting BAR domain-containing protein 1 isoform X5

    6. XM_063261264.1 → XP_063117334.1  CBY1-interacting BAR domain-containing protein 1 isoform X3

    7. XM_039110944.2 → XP_038966872.1  CBY1-interacting BAR domain-containing protein 1 isoform X7

      Conserved Domains (1) summary
      cl12013
      Location:78 → 156
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_010051710.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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