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    Cxcl10 C-X-C motif chemokine ligand 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245920, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cxcl10provided by RGD
    Official Full Name
    C-X-C motif chemokine ligand 10provided by RGD
    Primary source
    RGD:620209
    See related
    EnsemblRapid:ENSRNOG00000022256 AllianceGenome:RGD:620209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IP-10; Scyb10
    Summary
    Enables chemokine activity. Involved in several processes, including response to auditory stimulus; response to gamma radiation; and response to vitamin D. Located in extracellular space. Used to study adult respiratory distress syndrome; myocarditis; proteinuria; renovascular hypertension; and type 1 diabetes mellitus. Biomarker of brain infarction; brain ischemia; encephalitis; interstitial cystitis; and uveitis. Human ortholog(s) of this gene implicated in hepatitis B and middle cerebral artery infarction. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 165.6), Adrenal (RPKM 96.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Cxcl10 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (15989066..15991263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (15704772..15706969)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17210733..17212930)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 3 Neighboring gene CWF19 like cell cycle control factor 1, pseudogene 1 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene SDA1 domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CXCR chemokine receptor binding  
    enables CXCR3 chemokine receptor binding  
    enables CXCR3 chemokine receptor binding  
    enables chemoattractant activity  
    enables chemokine activity  
    enables chemokine activity PubMed 
    enables chemokine activity  
    enables chemokine activity PubMed 
    enables cytokine activity PubMed 
    enables heparin binding  
    Items 1 - 25 of 43
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway  
    involved_in T cell chemotaxis  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in antiviral innate immune response  
    involved_in cellular response to heat PubMed 
    involved_in cellular response to interleukin-17  
    involved_in cellular response to lipopolysaccharide  
    acts_upstream_of_or_within cellular response to lipopolysaccharide  
    involved_in cellular response to virus  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemokine-mediated signaling pathway  
    involved_in chemotaxis  
    involved_in chemotaxis  
    acts_upstream_of_or_within defense response to virus  
    involved_in endothelial cell activation  
    involved_in immune response PubMed 
    involved_in inflammatory response  
    involved_in negative regulation of angiogenesis PubMed 
    involved_in negative regulation of angiogenesis  
    acts_upstream_of_or_within negative regulation of myoblast differentiation  
    acts_upstream_of_or_within negative regulation of myoblast fusion  
    involved_in neutrophil chemotaxis  
    involved_in positive chemotaxis  
    acts_upstream_of_or_within positive regulation of T cell migration  
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of leukocyte chemotaxis PubMed 
    involved_in positive regulation of monocyte chemotaxis  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in regulation of T cell chemotaxis  
    involved_in regulation of apoptotic process  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cell population proliferation  
    involved_in regulation of endothelial tube morphogenesis  
    involved_in response to auditory stimulus PubMed 
    acts_upstream_of_or_within response to bacterium  
    involved_in response to gamma radiation PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to vitamin D PubMed 
    Items 1 - 25 of 43
    Component Evidence Code Pubs
    located_in external side of plasma membrane  
    located_in extracellular region  
    located_in extracellular region PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  

    General protein information

    Preferred Names
    C-X-C motif chemokine 10
    Names
    10 kDa interferon gamma-induced protein
    chemokine (C-X-C motif) ligand 10
    gamma-IP10
    interferon-inducible cytokine IP-10
    interferon-inducible protein 10
    protein Mob-1
    small inducible cytokine B subfamily (Cys-X-Cys) member 10
    small inducible cytokine B subfamily (Cys-X-Cys), member 10
    small-inducible cytokine B10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139089.2NP_620789.2  C-X-C motif chemokine 10 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P48973, P70538, Q6GTC7
      UniProtKB/TrEMBL
      A6KK92
      Related
      ENSRNOP00000003649.4, ENSRNOT00000003075.9
      Conserved Domains (1) summary
      cd00273
      Location:2789
      Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      15989066..15991263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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