Cdhr5 cadherin-related family member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdhr5provided by RGD
Official Full Name: cadherin-related family member 5provided by RGD
Primary source: RGD:620504
See related: EnsemblRapid:ENSRNOG00000017762 AllianceGenome:RGD:620504
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mucdhl; Mupcdh
Summary: Enables calcium ion binding activity. Involved in cell adhesion. Located in clathrin-coated pit. Orthologous to human CDHR5 (cadherin related family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 269.0) and Adrenal (RPKM 21.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205802686..205811184, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196373110..196381609, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214255118..214263848, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH131072 (e-PCR)
- UniSTS:214355

RH140929 (e-PCR)
- UniSTS:214355

AI481143 (e-PCR)
- UniSTS:159714

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in brush border assembly	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in intermicrovillar adhesion	ISO Inferred from Sequence Orthology more info
involved_in intermicrovillar adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microvillus length	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus length	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cadherin-related family member 5

Names: GP100; mu-protocadherin; mucin and cadherin like; mucin and cadherin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138525.2 → NP_612534.1 cadherin-related family member 5 precursor

See identical proteins and their annotated locations for NP_612534.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q4FZY9, Q9JIK1

UniProtKB/TrEMBL

A0A8I6AQ62, A6HXT3

Related

ENSRNOP00000044906.3, ENSRNOT00000044238.5

Conserved Domains (4) summary

pfam05568
Location:547 → 631

ASFV_J13L; African swine fever virus J13L protein

cd11304
Location:133 → 231

Cadherin_repeat; Cadherin tandem repeat domain

pfam02389
Location:507 → 649

Cornifin; Cornifin (SPRR) family

pfam13825
Location:477 → 537

Paramyxo_PNT; Paramyxovirus structural protein V/P N-terminus