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    Ppp2r2d protein phosphatase 2, regulatory subunit B, delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246255, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ppp2r2dprovided by RGD
    Official Full Name
    protein phosphatase 2, regulatory subunit B, deltaprovided by RGD
    Primary source
    RGD:708356
    See related
    EnsemblRapid:ENSRNOG00000016940 AllianceGenome:RGD:708356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme-substrate adaptor activity and protein phosphatase regulator activity. Predicted to be involved in exit from mitosis and regulation of chromosome segregation. Predicted to be located in nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Orthologous to human PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 185.9), Muscle (RPKM 159.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp2r2d in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203095536..203129895)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (193665918..193700277)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211205903..211240216)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transcription elongation regulator 1-like Neighboring gene uncharacterized LOC134485191 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 Neighboring gene uncharacterized LOC102553541 Neighboring gene BCL2 interacting protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. Strack S, et al. FEBS Lett, 1999 Nov 5. PMID 10556517
    2. Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Kabashima T, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12684532, Free PMC Article
    3. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ, et al. Mol Cell Biol, 2009 Feb. PMID 19029245, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Select PP2A heterotrimers oppose desensitization of the TrkA receptor tyrosine kinase, perhaps through dephosphorylation of inhibitory Ser/Thr phosphorylation sites on the receptor itself.
      Title: The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93154

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exit from mitosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144746.2 → NP_653347.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

      See identical proteins and their annotated locations for NP_653347.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081720
      UniProtKB/Swiss-Prot
      P56932, Q66HR7
      UniProtKB/TrEMBL
      A0A0G2JSQ0
      Related
      ENSRNOP00000023139.5, ENSRNOT00000023139.9
      Conserved Domains (3) summary
      COG5170
      Location:14 → 448
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:37 → 85
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:35 → 376
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      203095536..203129895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100143.2 → XP_038956071.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2

      Conserved Domains (2) summary
      COG5170
      Location:14 → 274
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:37 → 85
      7WD40; WD40 repeat [structural motif]

    2. XM_039100105.2 → XP_038956033.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

      UniProtKB/TrEMBL
      A6HX96, A6K6P2
      Conserved Domains (2) summary
      COG5170
      Location:2 → 283
      CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
      sd00039
      Location:21 → 57
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56932.1 GenPept UniProtKB/Swiss-Prot:P56932

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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