Stx6 syntaxin 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stx6provided by RGD
Official Full Name: syntaxin 6provided by RGD
Primary source: RGD:61915
See related: EnsemblRapid:ENSRNOG00000003402 AllianceGenome:RGD:61915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in endocytic recycling; retrograde transport, endosome to Golgi; and synaptic vesicle to endosome fusion. Located in recycling endosome and trans-Golgi network membrane. Is active in synaptic vesicle membrane. Orthologous to human STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 184.0), Thymus (RPKM 159.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (69882647..69928895)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (67332329..67378580)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (72804218..72850757)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 6 regulates nerve growth factor-dependent neurite outgrowth.
Title: Syntaxin 6 regulates nerve growth factor-dependent neurite outgrowth.
syntaxin 6 is involved in a membrane-trafficking step that sequesters Glut4 away from traffic destined for the plasma membrane
Title: Syntaxin 6 regulates Glut4 trafficking in 3T3-L1 adipocytes.
Syntaxin-6 has a role in secretory and endocytic pathways in pancreatic beta cells
Title: Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.
Depletion of MARCH-II by small interfering RNA perturbed the TGN localization of syntaxin 6 and TGN38/46
Title: MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138891 (e-PCR)
- UniSTS:220978

RH128466 (e-PCR)
- UniSTS:211774

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endosome organization	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle to endosome fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle to endosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	HDA more info	PubMed
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-6

Names: Syn6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031665.2 → NP_113853.1 syntaxin-6

See identical proteins and their annotated locations for NP_113853.1

Status: PROVISIONAL

Source sequence(s)

BC081769

UniProtKB/Swiss-Prot

Q63635

UniProtKB/TrEMBL

A6ICY5

Related

ENSRNOP00000103517.1, ENSRNOT00000128442.1

Conserved Domains (2) summary

cd15851
Location:166 → 231

SNARE_Syntaxin6; SNARE motif of syntaxin 6

cd21447
Location:5 → 107

SNARE_NTD_STX6; N-terminal domain of syntaxin-6