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    Fam120b family with sequence similarity 120 member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam120bprovided by RGD
    Official Full Name
    family with sequence similarity 120 member Bprovided by RGD
    Primary source
    RGD:1310304
    See related
    EnsemblRapid:ENSRNOG00000058790 AllianceGenome:RGD:1310304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310304
    Summary
    Predicted to be involved in fat cell differentiation and peroxisome proliferator activated receptor signaling pathway. Predicted to be active in nucleus. Orthologous to human FAM120B (family with sequence similarity 120 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 124.1), Kidney (RPKM 86.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam120b in Genome Data Viewer
    Location:
    1q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (64993104..65058160)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (56320015..56385064)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (57345559..57392114)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550720 Neighboring gene uncharacterized LOC134485093 Neighboring gene ribosomal protein SA, pseudogene 16 Neighboring gene delta like canonical Notch ligand 1 Neighboring gene uncharacterized LOC102557016 Neighboring gene proteasome 20S subunit beta 1 Neighboring gene TATA box binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. Li D, et al. Mol Endocrinol, 2007 Oct. PMID 17595322
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome proliferator activated receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    constitutive coactivator of peroxisome proliferator-activated receptor gamma
    Names
    family with sequence similarity 120B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107466.4 → NP_001100936.2  constitutive coactivator of peroxisome proliferator-activated receptor gamma

      See identical proteins and their annotated locations for NP_001100936.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K8J8, A6KB41, D4AE88
      Related
      ENSRNOP00000069852.2, ENSRNOT00000084017.3
      Conserved Domains (1) summary
      cd18672
      Location:5 → 213
      PIN_FAM120B-like; FEN-like PIN domains of FAM120B (family with sequence similarity 120B) and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      64993104..65058160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110798.2 → XP_038966726.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8J8, A6KB41, D4AE88
      Conserved Domains (1) summary
      cd18672
      Location:5 → 213
      PIN_FAM120B-like; FEN-like PIN domains of FAM120B (family with sequence similarity 120B) and related proteins

    2. XM_039110806.2 → XP_038966734.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8J8, A6KB41, D4AE88
      Related
      ENSRNOP00000107565.1, ENSRNOT00000133470.1
      Conserved Domains (1) summary
      cd18672
      Location:5 → 213
      PIN_FAM120B-like; FEN-like PIN domains of FAM120B (family with sequence similarity 120B) and related proteins

    3. XM_039110803.2 → XP_038966731.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8J8, A6KB41, D4AE88
      Conserved Domains (1) summary
      cd18672
      Location:5 → 213
      PIN_FAM120B-like; FEN-like PIN domains of FAM120B (family with sequence similarity 120B) and related proteins

    4. XM_039110811.2 → XP_038966739.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXF7
      Conserved Domains (1) summary
      cd18672
      Location:5 → 213
      PIN_FAM120B-like; FEN-like PIN domains of FAM120B (family with sequence similarity 120B) and related proteins

    5. XM_039110812.2 → XP_038966740.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8J8, A0A8I6A0B3
      Related
      ENSRNOP00000083603.1, ENSRNOT00000118789.2
      Conserved Domains (1) summary
      cd18672
      Location:5 → 213
      PIN_FAM120B-like; FEN-like PIN domains of FAM120B (family with sequence similarity 120B) and related proteins

    6. XM_063288585.1 → XP_063144655.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X4

    7. XM_063288575.1 → XP_063144645.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8J8, A6KB41, D4AE88

    8. XM_039110817.2 → XP_038966745.1  constitutive coactivator of peroxisome proliferator-activated receptor gamma isoform X5

    RNA

    1. XR_005504540.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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