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    Nucb2 nucleobindin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59295, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nucb2provided by RGD
    Official Full Name
    nucleobindin 2provided by RGD
    Primary source
    RGD:620888
    See related
    EnsemblRapid:ENSRNOG00000020456 AllianceGenome:RGD:620888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p54; Nefa
    Summary
    Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Located in Golgi medial cisterna and extracellular space. Biomarker of alcohol dependence; obesity; and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 302.2), Liver (RPKM 278.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nucb2 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (180185121..180221644)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (170750830..170787356)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (185106773..185143278, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Neighboring gene CCA tRNA nucleotidyltransferase 1, mitochondrial-like Neighboring gene RNA, U6 small nuclear 651 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables G-protein alpha-subunit binding PubMed 
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables tumor necrosis factor receptor binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi medial cisterna PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endomembrane system  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment  
    located_in endoplasmic reticulum-Golgi intermediate compartment  
    located_in extracellular space PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in nuclear outer membrane  
    located_in nucleus  

    General protein information

    Preferred Names
    nucleobindin-2
    Names
    DNA-binding protein NEFA
    nesfatin-1
    prepronefastin
    prepronesfatin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021663.2NP_067695.1  nucleobindin-2 precursor

      See identical proteins and their annotated locations for NP_067695.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061778
      UniProtKB/Swiss-Prot
      Q9JI85
      UniProtKB/TrEMBL
      A6I8F1
      Conserved Domains (3) summary
      pfam13499
      Location:247321
      EF-hand_7; EF-hand domain pair
      pfam14235
      Location:328383
      DUF4337; Domain of unknown function (DUF4337)
      cl08302
      Location:250321
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      180185121..180221644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230095.5XP_006230157.1  nucleobindin-2 isoform X1

      See identical proteins and their annotated locations for XP_006230157.1

      UniProtKB/TrEMBL
      A0A8I6GHJ0, A6I8F0, A6I8F1
      Related
      ENSRNOP00000027753.4, ENSRNOT00000027752.7
      Conserved Domains (3) summary
      pfam13499
      Location:247321
      EF-hand_7; EF-hand domain pair
      pfam14235
      Location:328383
      DUF4337; Domain of unknown function (DUF4337)
      cl08302
      Location:250321
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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