U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29295, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp2b12provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily b, polypeptide 12provided by RGD
    Primary source
    RGD:620088
    See related
    EnsemblRapid:ENSRNOG00000031529 AllianceGenome:RGD:620088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp2b15
    Summary
    Enables arachidonate epoxygenase activity. Involved in epoxygenase P450 pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cyp2b12 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91135294..91147094)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82007609..82019409)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (83511167..83522965)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene enhancer of polycomb homolog 2 (Drosophila)-like 1 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 14 like 1 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 14 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway  
    involved_in epoxygenase P450 pathway PubMed 
    involved_in xenobiotic metabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in endoplasmic reticulum membrane  
    is_active_in intracellular membrane-bounded organelle  

    General protein information

    Preferred Names
    cytochrome P450 2B12
    Names
    CYPIIB12
    cytochrome P-450b type b
    cytochrome P450, family 2, subfamily b, polypeptide 15
    NP_058852.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017156.2NP_058852.2  cytochrome P450 2B12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P33272
      UniProtKB/TrEMBL
      F1LMN1
      Related
      ENSRNOP00000048784.1, ENSRNOT00000041580.5
      Conserved Domains (1) summary
      cd20672
      Location:63487
      CYP2B; cytochrome P450 family 2, subfamily B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      91135294..91147094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.