U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmtc2 transmembrane O-mannosyltransferase targeting cadherins 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299762, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmtc2provided by RGD
    Official Full Name
    transmembrane O-mannosyltransferase targeting cadherins 2provided by RGD
    Primary source
    RGD:1309848
    See related
    EnsemblRapid:ENSRNOG00000004585 AllianceGenome:RGD:1309848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309848
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in calcium ion homeostasis and protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 80.8), Lung (RPKM 77.1) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmtc2 in Genome Data Viewer
    Location:
    7q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (42280746..42695651, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (40392377..40806685, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (47179596..47586777, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene BAF nuclear assembly factor 1, pseudogene 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479680 Neighboring gene uncharacterized LOC120093578 Neighboring gene uncharacterized LOC134479681 Neighboring gene methyltransferase like 25 Neighboring gene coiled-coil domain containing 59

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss. Runge CL, et al. JAMA Otolaryngol Head Neck Surg, 2016 Sep 1. PMID 27311106, Free PMC Article
    2. TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide repeat-containing adapter proteins involved in calcium homeostasis. Sunryd JC, et al. J Biol Chem, 2014 Jun 6. PMID 24764305, Free PMC Article
    3. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins. Larsen ISB, et al. Proc Natl Acad Sci U S A, 2017 Oct 17. PMID 28973932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein O-mannosyl-transferase TMTC2
    Names
    transmembrane and TPR repeat-containing protein 2
    transmembrane and tetratricopeptide repeat containing 2
    NP_001164648.2
    XP_038934631.1
    XP_038934632.1
    XP_038934634.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171177.2 → NP_001164648.2  protein O-mannosyl-transferase TMTC2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IGB5, F1M369
      Related
      ENSRNOP00000094183.2, ENSRNOT00000113359.2
      Conserved Domains (7) summary
      sd00006
      Location:527 → 555
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:779 → 812
      TPR_1; Tetratricopeptide repeat
      pfam07719
      Location:609 → 638
      TPR_2; Tetratricopeptide repeat
      pfam08409
      Location:247 → 321
      DUF1736; Domain of unknown function (DUF1736)
      pfam13414
      Location:493 → 554
      TPR_11; TPR repeat
      pfam13424
      Location:557 → 634
      TPR_12; Tetratricopeptide repeat
      pfam14559
      Location:755 → 822
      TPR_19; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      42280746..42695651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078704.2 → XP_038934632.1  protein O-mannosyl-transferase TMTC2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALM4
      Conserved Domains (3) summary
      COG0457
      Location:491 → 689
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:527 → 555
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:248 → 321
      DUF1736; Domain of unknown function (DUF1736)

    2. XM_039078703.2 → XP_038934631.1  protein O-mannosyl-transferase TMTC2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5J6, A0A8I6ALM4
      Related
      ENSRNOP00000086192.1, ENSRNOT00000093853.2
      Conserved Domains (3) summary
      COG0457
      Location:481 → 722
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:527 → 555
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:248 → 321
      DUF1736; Domain of unknown function (DUF1736)

    3. XM_039078706.2 → XP_038934634.1  protein O-mannosyl-transferase TMTC2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALM4
      Conserved Domains (3) summary
      COG0457
      Location:491 → 689
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:527 → 555
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:248 → 321
      DUF1736; Domain of unknown function (DUF1736)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools