Mki67 marker of proliferation Ki-67 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mki67provided by RGD
Official Full Name: marker of proliferation Ki-67provided by RGD
Primary source: RGD:1305476
See related: EnsemblRapid:ENSRNOG00000028137 AllianceGenome:RGD:1305476
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in several processes, including DNA metabolic process; animal organ regeneration; and cellular response to heat. Located in nucleus. Used to study high grade glioma; leiomyoma; and prostate carcinoma. Biomarker of several diseases, including alcohol use disorder; colon cancer; mucositis; type 2 diabetes mellitus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 1569.5), Spleen (RPKM 1565.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (199926150..199952847, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (190496319..190522983, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (207993895..208020454, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Quantitative Assessment of Epithelial Proliferation in Rat Mammary Gland Using Artificial Intelligence Independent of Choice of Proliferation Marker.
Title: Quantitative Assessment of Epithelial Proliferation in Rat Mammary Gland Using Artificial Intelligence Independent of Choice of Proliferation Marker.
Data show that the positive expression of proliferating cell nuclear antigen (PCNA) and Ki-67 antigen (Ki-67) is related to the fluoride-induced spermatogenesis dysfunction in the testis.
Title: Positive PCNA and Ki-67 Expression in the Testis Correlates with Spermatogenesis Dysfunction in Fluoride-Treated Rats.
The higher KI-67 PI and Mitotic activity index (MAI) in 1-methyl-1-nitrosourea-(MNU)-induced mammary carcinomas are suggestive of a higher aggressiveness of these carcinomas when compared with the 7,12-dimethylbenz[a]anthracene (DMBA)-induced ones, and consequently a worse response to the therapy and a worse prognosis.
Title: Prognostic factors in MNU and DMBA-induced mammary tumors in female rats.
During postnatal development there was a positive correlation with Ki-67 and active caspase-3 in the dentate gyrus.
Title: Immunoreactivity of Ki-67/β-tubulin and immunocolocalization with active caspase-3 in rat dentate gyrus during postnatal development.
ATRA increases the number of glomerular epithelial transition cells in experimental proteinuric glomerular diseases. Thus, ATRA may provide a useful pharmacologic approach to decipher the
Title: Retinoids augment the expression of podocyte proteins by glomerular parietal epithelial cells in experimental glomerular disease.
Sixty days of exposure to tobacco smoke resulted only in benign lesions, as confirmed by analysis of p53 and ki-67 expression analysis.
Title: Histological and immunohistochemical study of the expression of p53 and ki-67 proteins in the mucosa of the tongue, pharynx and larynx of rats exposed to cigarette smoke.
Bevacizumab prevented postoperative adhesion formation in a rat uterine horn adhesion model and decreased Ki-67 positive cells.
Title: Effect of bevacizumab on postoperative adhesion formation in a rat uterine horn adhesion model and the correlation with vascular endothelial growth factor and Ki-67 immunopositivity.
Data suggest that MT1-MMP and TIMP-2 may have some role in cell proliferation during the eruption of the rat incisor tooth.
Title: Increase of MT1-MMP, TIMP-2 and Ki-67 proteins in the odontogenic region of the rat incisor post-shortening procedure.
bcl-2, bax, c-erb-B2 and Ki67 have roles in carcinogen-induced tongue carcinoma in rat
Title: Effect of dietary and topical Celecoxib on expression of bcl-2, bax, c-erb-B2 and Ki67 in carcinogen-induced tongue carcinoma in rat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholangiocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within stem cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
is_active_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proliferation marker protein Ki-67

Names: antigen KI-67; antigen identified by monoclonal antibody Ki-67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271366.1 → NP_001258295.1 proliferation marker protein Ki-67

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D4A0Y6

Conserved Domains (4) summary

COG1716
Location:4 → 118

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:7 → 101

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam08065
Location:1110 → 1218

K167R; K167R (NUC007) repeat

pfam15276
Location:463 → 504

PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

199926150..199952847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230453.4 → XP_006230515.1 proliferation marker protein Ki-67 isoform X1

UniProtKB/TrEMBL

D4A0Y6

Related

ENSRNOP00000038727.6, ENSRNOT00000038176.7

Conserved Domains (4) summary

COG1716
Location:4 → 118

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:7 → 101

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam08065
Location:1110 → 1218

K167R; K167R (NUC007) repeat

pfam15276
Location:463 → 504

PP1_bind; Protein phosphatase 1 binding