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    Nup98 nucleoporin 98 and 96 precursor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81738, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nup98provided by RGD
    Official Full Name
    nucleoporin 98 and 96 precursorprovided by RGD
    Primary source
    RGD:71033
    See related
    EnsemblRapid:ENSRNOG00000020347 AllianceGenome:RGD:71033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables nuclear localization sequence binding activity. Involved in protein import into nucleus. Located in nucleus. Part of nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 168.4), Adrenal (RPKM 166.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nup98 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165906405..166003366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156494423..156591415, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167213866..167308851, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene glutathione peroxidase 4, pseudogene 1 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA binding  
    enables molecular condensate scaffold activity  
    enables nuclear localization sequence binding  
    enables nuclear localization sequence binding PubMed 
    enables peptide binding PubMed 
    enables promoter-specific chromatin binding  
    enables promoter-specific chromatin binding  
    enables protein binding PubMed 
    enables serine-type peptidase activity  
    enables structural constituent of nuclear pore  
    enables structural constituent of nuclear pore  
    enables structural constituent of nuclear pore  
    enables structural constituent of nuclear pore  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus  
    involved_in mRNA transport  
    involved_in nuclear pore complex assembly  
    involved_in nuclear pore complex assembly  
    involved_in nucleocytoplasmic transport  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of mRNA splicing, via spliceosome  
    involved_in positive regulation of mRNA splicing, via spliceosome  
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery  
    involved_in protein import into nucleus  
    involved_in protein import into nucleus PubMed 
    involved_in protein transport  
    involved_in proteolysis  
    involved_in telomere tethering at nuclear periphery  
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    located_in kinetochore  
    located_in nuclear body  
    located_in nuclear envelope  
    located_in nuclear inclusion body PubMed 
    located_in nuclear inclusion body  
    located_in nuclear membrane PubMed 
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nuclear periphery PubMed 
    located_in nuclear periphery  
    located_in nuclear periphery  
    part_of nuclear pore PubMed 
    part_of nuclear pore  
    part_of nuclear pore  
    part_of nuclear pore  
    part_of nuclear pore cytoplasmic filaments  
    part_of nuclear pore nuclear basket PubMed 
    part_of nuclear pore nuclear basket  
    part_of nuclear pore outer ring  
    part_of nuclear pore outer ring  
    located_in nucleoplasm PubMed 
    located_in nucleoplasm  
    located_in nucleus  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    nuclear pore complex protein Nup98-Nup96
    Names
    98 kDa nucleoporin
    nuclear pore complex protein Nup98
    nucleoporin 98kDa
    nucleoporin Nup98

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031074.3NP_112336.2  nuclear pore complex protein Nup98-Nup96 proprotein

      See identical proteins and their annotated locations for NP_112336.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D3ZMW4, P49793
      UniProtKB/TrEMBL
      A0A8I6ALK1
      Related
      ENSRNOP00000027575.5, ENSRNOT00000027575.9
      Conserved Domains (4) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13331624
      Nup96; Nuclear protein 96
      pfam13634
      Location:25149
      Nucleoporin_FG; Nucleoporin FG repeat region
      pfam16768
      Location:26336
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      165906405..166003366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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