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    Misp mitotic spindle positioning [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mispprovided by RGD
    Official Full Name
    mitotic spindle positioningprovided by RGD
    Primary source
    RGD:1595680
    See related
    EnsemblRapid:ENSRNOG00000010423 AllianceGenome:RGD:1595680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including establishment of centrosome localization; microtubule cytoskeleton organization involved in mitosis; and regulation of protein localization to cell cortex. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Orthologous to human MISP (mitotic spindle positioning). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 20.5), Lung (RPKM 9.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Misp in Genome Data Viewer
    Location:
    7q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10526980..10537159, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9870390..9886541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12691834..12707927, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene uncharacterized LOC134479815 Neighboring gene uncharacterized LOC134479814 Neighboring gene paralemmin Neighboring gene serine protease 57

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Maier B, et al. Cell Cycle, 2013 May 1. PMID 23574715, Free PMC Article
    2. MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. Zhu M, et al. J Cell Biol, 2013 Mar 18. PMID 23509069, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organelle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle astral microtubule end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitotic interactor and substrate of PLK1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109284.1 → NP_001102754.1  mitotic interactor and substrate of PLK1

      See identical proteins and their annotated locations for NP_001102754.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A0A8I6GB45, A6K8W8, D3ZHV9
      Related
      ENSRNOP00000013857.4, ENSRNOT00000013857.7
      Conserved Domains (1) summary
      pfam15304
      Location:296 → 646
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10526980..10537159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264096.1 → XP_063120166.1  mitotic interactor and substrate of PLK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB45, A6K8W8, D3ZHV9

    2. XM_063264095.1 → XP_063120165.1  mitotic interactor and substrate of PLK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB45, A6K8W8, D3ZHV9

    3. XM_017595045.3 → XP_017450534.1  mitotic interactor and substrate of PLK1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GB45, A6K8W8, D3ZHV9
      Conserved Domains (1) summary
      pfam15304
      Location:296 → 646
      AKAP2_C; A-kinase anchor protein 2 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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