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    Spire2 spire-type actin nucleation factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spire2provided by RGD
    Official Full Name
    spire-type actin nucleation factor 2provided by RGD
    Primary source
    RGD:1305837
    See related
    EnsemblRapid:ENSRNOG00000016920 AllianceGenome:RGD:1305837
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of double-strand break repair. Predicted to be located in cleavage furrow. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Orthologous to human SPIRE2 (spire type actin nucleation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 39.0), Testes (RPKM 26.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spire2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68281878..68320427)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51373368..51411920)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56136904..56175500)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein (C2H2 type) 276 Neighboring gene small nucleolar RNA SNORD43 Neighboring gene FA complementation group A Neighboring gene TCF25 ribosome quality control complex subunit Neighboring gene melanocortin 1 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. Belin BJ, et al. Elife, 2015 Aug 19. PMID 26287480, Free PMC Article
    2. An actin-dependent mechanism for long-range vesicle transport. Schuh M. Nat Cell Biol, 2011 Oct 9. PMID 21983562, Free PMC Article
    3. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Pfender S, et al. Curr Biol, 2011 Jun 7. PMID 21620703, Free PMC Article
    4. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cleavage furrow formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of meiotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of meiotic spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formin-nucleated actin cable assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polar body extrusion after meiotic divisions IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polar body extrusion after meiotic divisions ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein spire homolog 2
    Names
    spire homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127538.2 → NP_001121010.2  protein spire homolog 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZX8, B2RYF2, G3V870
      Related
      ENSRNOP00000022823.4, ENSRNOT00000022823.8
      Conserved Domains (6) summary
      cl28890
      Location:566 → 680
      FYVE_like_SF; FYVE domain like superfamily
      pfam16474
      Location:26 → 212
      KIND; Kinase non-catalytic C-lobe domain
      cd22065
      Location:237 → 268
      WH2_Spire_1-2_r1; first tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2
      cd22079
      Location:279 → 308
      WH2_Spire2_r2; second tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 2
      cd22081
      Location:343 → 364
      WH2_Spire2_r4; fourth tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homolog 2
      cd22186
      Location:311 → 333
      WH2_Spire1-2_r3; third tandem Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif) repeat of protein Spire homologs 1 and 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68281878..68320427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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