Pla2g7 phospholipase A2 group VII [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g7provided by RGD
Official Full Name: phospholipase A2 group VIIprovided by RGD
Primary source: RGD:1310734
See related: EnsemblRapid:ENSRNOG00000025691 AllianceGenome:RGD:1310734
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in several processes, including glycerophospholipid catabolic process; plasma lipoprotein particle remodeling; and positive regulation of monocyte chemotaxis. Located in extracellular space. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 34.6), Spleen (RPKM 29.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (24859491..24901747, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (17362214..17404476, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (19935754..19978013, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show an increase of liver group VII phospholipase A2 gene expression in the obese animals together with a strong specific inhibition of type IVA and VIA phospholipases A2.
Title: The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISO Inferred from Sequence Orthology more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in lipid oxidation	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle oxidation	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet-activating factor acetylhydrolase

Names: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

NP_001009353.1

EC 3.1.1.47

XP_006244668.1

EC 3.1.1.47

XP_063122939.1

EC 3.1.1.47

XP_063122940.1

EC 3.1.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009353.1 → NP_001009353.1 platelet-activating factor acetylhydrolase precursor

See identical proteins and their annotated locations for NP_001009353.1

Status: PROVISIONAL

Source sequence(s)

BC088457

UniProtKB/TrEMBL

A0A8I6GE94, A6JJ34, A6JJ35, Q5M7T7

Related

ENSRNOP00000031958.3, ENSRNOT00000038222.6

Conserved Domains (1) summary

pfam03403
Location:47 → 415

PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

24859491..24901747 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266869.1 → XP_063122939.1 platelet-activating factor acetylhydrolase isoform X2

UniProtKB/TrEMBL

A0A8I6GE94

Related

ENSRNOP00000107961.1, ENSRNOT00000138099.1
XM_006244606.5 → XP_006244668.1 platelet-activating factor acetylhydrolase isoform X1

UniProtKB/TrEMBL

A0A8I6GE94

Related

ENSRNOP00000085766.2, ENSRNOT00000119925.2

Conserved Domains (1) summary

pfam03403
Location:80 → 448

PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
XM_063266870.1 → XP_063122940.1 platelet-activating factor acetylhydrolase isoform X3