Camkmt calmodulin-lysine N-methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camkmtprovided by RGD
Official Full Name: calmodulin-lysine N-methyltransferaseprovided by RGD
Primary source: RGD:1310453
See related: EnsemblRapid:ENSRNOG00000030629 AllianceGenome:RGD:1310453
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CLNMT; CaM KMT; RGD1310453
Summary: Predicted to enable calmodulin-lysine N-methyltransferase activity and heat shock protein binding activity. Predicted to be involved in methylation. Predicted to act upstream of or within mitochondrion organization and peptidyl-lysine methylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human CAMKMT (calmodulin-lysine N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 48.1), Lung (RPKM 42.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (14951838..15332966, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (9198945..9580200, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (8346645..8729773)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141573 (e-PCR)
- UniSTS:223567

RH136925 (e-PCR)
- UniSTS:219014

UniSTS:237721 (e-PCR)
- UniSTS:237721

D6Rat214 (e-PCR), detects polymorphism
- UniSTS:228051

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-lysine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calmodulin-lysine N-methyltransferase

NP_001127935.1

EC 2.1.1.60

XP_038968049.1

EC 2.1.1.60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134463.1 → NP_001127935.1 calmodulin-lysine N-methyltransferase

See identical proteins and their annotated locations for NP_001127935.1

Status: PROVISIONAL

Source sequence(s)

BC159411

UniProtKB/Swiss-Prot

B0K012

UniProtKB/TrEMBL

A6H9G9

Related

ENSRNOP00000048187.4, ENSRNOT00000048550.5

Conserved Domains (1) summary

cl17173
Location:113 → 278

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...