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    Insc INSC, spindle orientation adaptor protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inscprovided by RGD
    Official Full Name
    INSC, spindle orientation adaptor proteinprovided by RGD
    Primary source
    RGD:1311379
    See related
    EnsemblRapid:ENSRNOG00000024712 AllianceGenome:RGD:1311379
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311379
    Summary
    Predicted to enable cytoskeletal anchor activity and protein domain specific binding activity. Predicted to be involved in several processes, including apical protein localization; establishment of mitotic spindle orientation; and regulation of asymmetric cell division. Predicted to act upstream of or within lung epithelial cell differentiation. Predicted to be located in apical part of cell; cell cortex; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in apical cortex. Orthologous to human INSC (INSC spindle orientation adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 53.6), Lung (RPKM 18.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Insc in Genome Data Viewer
    Location:
    1q34
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (178427360..178534827)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (168993032..169100438)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (184299200..184407487)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcitonin-related polypeptide alpha Neighboring gene calcitonin-related polypeptide, beta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134485166 Neighboring gene uncharacterized LOC134484912

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. Izaki T, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16458856
    2. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Yuzawa S, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22074847, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apical protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asymmetric cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of asymmetric cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein inscuteable homolog
    Names
    inscuteable homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106285.1 → NP_001099755.1  protein inscuteable homolog

      See identical proteins and their annotated locations for NP_001099755.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6I8C1, A6I8C2, D3ZFP7
      Related
      ENSRNOP00000031361.4, ENSRNOT00000030540.7
      Conserved Domains (1) summary
      pfam16748
      Location:70 → 113
      INSC_LBD; Inscuteable LGN-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      178427360..178534827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285287.1 → XP_063141357.1  protein inscuteable homolog isoform X1

      UniProtKB/TrEMBL
      A6I8C2
      Related
      ENSRNOP00000074463.3, ENSRNOT00000078096.3

    2. XM_039106440.2 → XP_038962368.1  protein inscuteable homolog isoform X4

      UniProtKB/TrEMBL
      A6I8C2
      Conserved Domains (1) summary
      pfam16748
      Location:1 → 19
      INSC_LBD; Inscuteable LGN-binding domain

    3. XM_039106438.2 → XP_038962366.1  protein inscuteable homolog isoform X3

      UniProtKB/TrEMBL
      A6I8C2
      Conserved Domains (1) summary
      pfam16748
      Location:1 → 44
      INSC_LBD; Inscuteable LGN-binding domain

    4. XM_017588972.3 → XP_017444461.1  protein inscuteable homolog isoform X2

      UniProtKB/TrEMBL
      A6I8C2
      Related
      ENSRNOP00000102436.1, ENSRNOT00000169476.1

    5. XM_039106441.2 → XP_038962369.1  protein inscuteable homolog isoform X5

      Conserved Domains (1) summary
      pfam16748
      Location:25 → 68
      INSC_LBD; Inscuteable LGN-binding domain

    6. XM_063285288.1 → XP_063141358.1  protein inscuteable homolog isoform X2

      UniProtKB/TrEMBL
      A6I8C2
    Nucleotide Protein Strain
    Heading Accession and Version

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