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    Ppme1 protein phosphatase methylesterase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361613, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppme1provided by RGD
    Official Full Name
    protein phosphatase methylesterase 1provided by RGD
    Primary source
    RGD:1309683
    See related
    EnsemblRapid:ENSRNOG00000017227 AllianceGenome:RGD:1309683
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PME-1; RGD1309683
    Summary
    Enables protein kinase binding activity. Predicted to be involved in protein demethylation and protein phosphorylation. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 214.6), Kidney (RPKM 97.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppme1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164080242..164127261, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154668099..154715079, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165335242..165382216, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 2-like 1 Neighboring gene prolyl 4-hydroxylase subunit alpha 3 Neighboring gene uncharacterized LOC120099892 Neighboring gene C2 domain containing 3 centriole elongation regulator Neighboring gene uncoupling protein 3

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lncRNA binding  
    enables protein C-terminal methylesterase activity  
    enables protein C-terminal methylesterase activity  
    enables protein kinase binding PubMed 
    enables protein phosphatase 2A binding  
    enables protein phosphatase binding  
    enables protein phosphatase regulator activity PubMed 

    General protein information

    Preferred Names
    protein phosphatase methylesterase 1
    NP_001178767.1
    XP_063123246.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191838.1NP_001178767.1  protein phosphatase methylesterase 1

      See identical proteins and their annotated locations for NP_001178767.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q4FZT2
      UniProtKB/TrEMBL
      A6I6M6
      Related
      ENSRNOP00000023649.8, ENSRNOT00000023648.9
      Conserved Domains (1) summary
      COG0596
      Location:66370
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164080242..164127261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267176.1XP_063123246.1  protein phosphatase methylesterase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q4FZT2
      UniProtKB/TrEMBL
      A6I6M6
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