Umod uromodulin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Umodprovided by RGD
Official Full Name: uromodulinprovided by RGD
Primary source: RGD:3940
See related: EnsemblRapid:ENSRNOG00000015557 AllianceGenome:RGD:3940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: THP
Summary: Predicted to enable IgG binding activity. Predicted to be involved in several processes, including defense response to bacterium; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and metanephric nephron tubule development. Predicted to act upstream of or within with a positive effect on protein phosphorylation. Predicted to act upstream of or within several processes, including citric acid secretion; intracellular monoatomic cation homeostasis; and kidney development. Located in apical part of cell and extracellular space. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human UMOD (uromodulin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 8401.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183247676..183261665, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (173816341..173829681, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189186027..189199939, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two forms of uromodulin (polymerization competent and polymerization incompetent) were found in urine from both Wistar-Kyoto and SHRSP, where the polymerization-incompetent form was increased in a pregnancy-specific manner in stroke-prone spontaneously hypertensive rats.
Title: Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.
The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens.
Title: Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules.
Sepsis-induced renal Cox-2 expression on TLR4 is tubule specific. The TLR4-dependent Cox-2 expression is mostly restricted to cortical and medullary thick ascending loops of Henle that characteristically express and secrete Tamm-Horsfall protein.
Title: Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent.
Tamm-Horsfall protein derived from hyperoxaluric rats exhibited 2-fold increase in the Ca*Ox binding when compared to controls
Title: Oral L-arginine supplementation ameliorates urinary risk factors and kinetic modulation of Tamm-Horsfall glycoprotein in experimental hyperoxaluric rats.
results demonstrate a selective decrease in medullary THP synthesis, suggesting a potential involvement of THP in the renal functional changes associated with hypothyroidism
Title: Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgG binding	IEA Inferred from Electronic Annotation more info
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERAD pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in antibacterial innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial innate immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within citric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collecting duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within connective tissue replacement	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within juxtaglomerular apparatus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within loop of Henle development	ISO Inferred from Sequence Orthology more info
involved_in metanephric ascending thin limb development	ISO Inferred from Sequence Orthology more info
involved_in metanephric distal convoluted tubule development	ISO Inferred from Sequence Orthology more info
involved_in metanephric thick ascending limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within micturition	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil migration	IEA Inferred from Electronic Annotation more info
involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within organ or tissue specific immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to vacuole	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport into plasma membrane raft	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of urine volume	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal sodium ion absorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal urate salt excretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal water homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to unfolded protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to water deprivation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urea transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: uromodulin

Names: Urmodulin (Tamm-Horsfall protein); tamm-Horsfall urinary glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017082.2 → NP_058778.2 uromodulin precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P27590, Q642D6

Related

ENSRNOP00000082923.2, ENSRNOT00000096977.2

Conserved Domains (3) summary

smart00179
Location:67 → 108

EGF_CA; Calcium-binding EGF-like domain

smart00241
Location:337 → 586

ZP; Zona pellucida (ZP) domain

pfam12947
Location:120 → 149

EGF_3; EGF domain