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    Fchsd2 FCH and double SH3 domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308864, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fchsd2provided by RGD
    Official Full Name
    FCH and double SH3 domains 2provided by RGD
    Primary source
    RGD:1304812
    See related
    EnsemblRapid:ENSRNOG00000019319 AllianceGenome:RGD:1304812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including clathrin-dependent endocytosis; neuromuscular synaptic transmission; and positive regulation of supramolecular fiber organization. Predicted to be located in clathrin-coated pit; plasma membrane; and stereocilium shaft. Predicted to be active in neuromuscular junction and recycling endosome. Orthologous to human FCHSD2 (FCH and double SH3 domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 166.1), Thymus (RPKM 128.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fchsd2 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164775916..165097391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (155444471..155685350)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166140025..166395915)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102 Neighboring gene pyrimidinergic receptor P2Y6 Neighboring gene purinergic receptor P2Y2 Neighboring gene uncharacterized LOC120097346 Neighboring gene ribosomal protein L7a, pseudogene 36 Neighboring gene autophagy related 16-like 2 Neighboring gene StAR-related lipid transfer domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in clathrin-coated pit  
    is_active_in neuromuscular junction  
    located_in plasma membrane  
    is_active_in recycling endosome  
    located_in stereocilium shaft  

    General protein information

    Preferred Names
    F-BAR and double SH3 domains protein 2
    Names
    FCH and double SH3 domains protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395742.1NP_001382671.1  F-BAR and double SH3 domains protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6G358, D3ZCY3
      Related
      ENSRNOP00000079354.1, ENSRNOT00000113808.2
      Conserved Domains (3) summary
      cd07677
      Location:16275
      F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
      cd11761
      Location:471527
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:571626
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164775916..165097391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262815.1XP_063118885.1  F-BAR and double SH3 domains protein 2 isoform X2

      Related
      ENSRNOP00000048024.5, ENSRNOT00000042524.6
    2. XM_063262816.1XP_063118886.1  F-BAR and double SH3 domains protein 2 isoform X2

    3. XM_008759721.4XP_008757943.2  F-BAR and double SH3 domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K219, D3ZCY3
      Related
      ENSRNOP00000072072.2, ENSRNOT00000091822.3
      Conserved Domains (3) summary
      cd07677
      Location:16275
      F-BAR_FCHSD2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains 2 (FCHSD2)
      cd11761
      Location:495551
      SH3_FCHSD_1; First Src Homology 3 domain of FCH and double SH3 domains proteins
      cd11894
      Location:595650
      SH3_FCHSD2_2; Second Src Homology 3 domain of FCH and double SH3 domains protein 2
    4. XM_063262817.1XP_063118887.1  F-BAR and double SH3 domains protein 2 isoform X3

      UniProtKB/TrEMBL
      A6I6S8

    RNA

    1. XR_005506100.2 RNA Sequence

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