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    Adgre1 adhesion G protein-coupled receptor E1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgre1provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor E1provided by RGD
    Primary source
    RGD:1359214
    See related
    EnsemblRapid:ENSRNOG00000046254 AllianceGenome:RGD:1359214
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Emr1
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in cellular response to transforming growth factor beta stimulus and cellular response to tumor necrosis factor. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 192.2), Liver (RPKM 101.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgre1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (2329398..2484959)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (2242476..2398000)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9431888..9585883, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 3A Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene heat shock protein family A (Hsp70) member 14, pseudogene 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene vomeronasal 2 receptor, pseudogene 140 Neighboring gene vomeronasal 2 receptor, 79

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The EGF-TM7 family of the rat. Hamann J. Immunogenetics, 2004 Dec. PMID 15578266
    2. Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. McKnight AJ, et al. J Biol Chem, 1996 Jan 5. PMID 8550607
    3. CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver. Yang CY, et al. PLoS One, 2013. PMID 23762286, Free PMC Article
    4. Dectin-1 is a major beta-glucan receptor on macrophages. Brown GD, et al. J Exp Med, 2002 Aug 5. PMID 12163569, Free PMC Article
    5. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, et al. PLoS One, 2012. PMID 23110133, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor E2
    Names
    EGF-like module containing, mucin-like, hormone receptor-like sequence 1
    EGF-like module receptor 1
    EGF-like module-containing mucin-like hormone receptor-like 1
    EMR1 hormone receptor
    cell surface glycoprotein EMR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007557.2 → NP_001007558.1  adhesion G protein-coupled receptor E2 precursor

      See identical proteins and their annotated locations for NP_001007558.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5Y4N8
      UniProtKB/TrEMBL
      A0A8I5ZPM3, A6KQQ5
      Related
      ENSRNOP00000067220.1, ENSRNOT00000073926.4
      Conserved Domains (6) summary
      smart00303
      Location:592 → 641
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133 → 172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:33 → 63
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00002
      Location:646 → 886
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam07645
      Location:319 → 359
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:245 → 275
      cEGF; Complement Clr-like EGF-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      2329398..2484959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244280.5 → XP_006244342.1  adhesion G protein-coupled receptor E2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZPM3, A0A8I5ZYF2
      Related
      ENSRNOP00000084080.1, ENSRNOT00000105310.2
      Conserved Domains (6) summary
      smart00303
      Location:592 → 641
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133 → 172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:33 → 63
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:319 → 359
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:245 → 275
      cEGF; Complement Clr-like EGF-like
      cl21561
      Location:637 → 821
      7tm_4; Olfactory receptor

    2. XM_039083468.2 → XP_038939396.1  adhesion G protein-coupled receptor E2 isoform X3

      Conserved Domains (6) summary
      smart00303
      Location:592 → 641
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133 → 172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:33 → 63
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam12662
      Location:245 → 275
      cEGF; Complement Clr-like EGF-like
      cd14964
      Location:647 → 672
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:645 → 709
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_039083467.2 → XP_038939395.1  adhesion G protein-coupled receptor E2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPM3
      Related
      ENSRNOP00000106082.1, ENSRNOT00000156968.1
      Conserved Domains (6) summary
      smart00303
      Location:571 → 620
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:112 → 151
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:12 → 42
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:298 → 338
      EGF_CA; Calcium-binding EGF domain
      cd15439
      Location:624 → 886
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam12662
      Location:224 → 254
      cEGF; Complement Clr-like EGF-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5Y4N8.1 GenPept UniProtKB/Swiss-Prot:Q5Y4N8

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