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    Rin2 Ras and Rab interactor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rin2provided by RGD
    Official Full Name
    Ras and Rab interactor 2provided by RGD
    Primary source
    RGD:1305873
    See related
    EnsemblRapid:ENSRNOG00000010131 AllianceGenome:RGD:1305873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of vasculogenesis. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN2 (Ras and Rab interactor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 169.1), Kidney (RPKM 114.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rin2 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (153540147..153756897)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (133086858..133303604)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (139871330..140087679)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 member 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350484 Neighboring gene U4 spliceosomal RNA Neighboring gene probable rRNA-processing protein EBP2 pseudogene Neighboring gene transfer RNA threonine (anticodon AGU) 15 Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit Neighboring gene cilia and flagella associated protein 61 Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Sandri C, et al. Cell Res, 2012 Oct. PMID 22825554, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras and Rab interactor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107786.2 → NP_001101256.1  ras and Rab interactor 2

      See identical proteins and their annotated locations for NP_001101256.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6K774, D4A6C4
      Conserved Domains (3) summary
      smart00167
      Location:658 → 774
      VPS9; Domain present in VPS9
      cd01776
      Location:798 → 884
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins

    2. NM_001434033.1 → NP_001420962.1  ras and Rab interactor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6K774, D4A6C4

    3. NM_001434034.1 → NP_001420963.1  ras and Rab interactor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6K774, D4A6C4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      153540147..153756897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283806.1 → XP_063139876.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A6K774, D4A6C4

    2. XM_006235142.5 → XP_006235204.1  ras and Rab interactor 2 isoform X1

      See identical proteins and their annotated locations for XP_006235204.1

      UniProtKB/TrEMBL
      A6K774, D4A6C4
      Conserved Domains (3) summary
      smart00167
      Location:658 → 774
      VPS9; Domain present in VPS9
      cd01776
      Location:798 → 884
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins

    3. XM_017591763.3 → XP_017447252.1  ras and Rab interactor 2 isoform X1

      Related
      ENSRNOP00000059327.1, ENSRNOT00000064695.4
      Conserved Domains (3) summary
      smart00167
      Location:658 → 774
      VPS9; Domain present in VPS9
      cd01776
      Location:798 → 884
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins

    4. XM_017591764.3 → XP_017447253.1  ras and Rab interactor 2 isoform X1

      Conserved Domains (3) summary
      smart00167
      Location:658 → 774
      VPS9; Domain present in VPS9
      cd01776
      Location:798 → 884
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins

    5. XM_063283807.1 → XP_063139877.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A6K774, D4A6C4

    6. XM_006235146.5 → XP_006235208.1  ras and Rab interactor 2 isoform X1

      See identical proteins and their annotated locations for XP_006235208.1

      UniProtKB/TrEMBL
      A6K774, D4A6C4
      Conserved Domains (3) summary
      smart00167
      Location:658 → 774
      VPS9; Domain present in VPS9
      cd01776
      Location:798 → 884
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins

    7. XM_063283805.1 → XP_063139875.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A6K774, D4A6C4
      Related
      ENSRNOP00000106504.1, ENSRNOT00000155461.1

    8. XM_006235148.5 → XP_006235210.1  ras and Rab interactor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUT7
      Related
      ENSRNOP00000083107.1, ENSRNOT00000096314.2
      Conserved Domains (3) summary
      smart00167
      Location:642 → 758
      VPS9; Domain present in VPS9
      cd01776
      Location:782 → 868
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cd10394
      Location:70 → 169
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins

    9. XM_017591766.3 → XP_017447255.1  ras and Rab interactor 2 isoform X4

      Conserved Domains (3) summary
      smart00167
      Location:605 → 721
      VPS9; Domain present in VPS9
      cd10394
      Location:33 → 132
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:742 → 832
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    10. XM_063283808.1 → XP_063139878.1  ras and Rab interactor 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K2D2, A6K775
      Related
      ENSRNOP00000072197.1, ENSRNOT00000086409.3

    11. XM_006235150.5 → XP_006235212.1  ras and Rab interactor 2 isoform X3

      See identical proteins and their annotated locations for XP_006235212.1

      UniProtKB/TrEMBL
      A0A0G2K2D2, A6K775
      Conserved Domains (3) summary
      smart00167
      Location:636 → 752
      VPS9; Domain present in VPS9
      cd01776
      Location:776 → 862
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cd10394
      Location:64 → 163
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins

    12. XM_039105047.2 → XP_038960975.1  ras and Rab interactor 2 isoform X4

      Conserved Domains (3) summary
      smart00167
      Location:605 → 721
      VPS9; Domain present in VPS9
      cd10394
      Location:33 → 132
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:742 → 832
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
    Nucleotide Protein Strain
    Heading Accession and Version

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