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    Zfp846 zinc finger protein 846 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp846provided by RGD
    Official Full Name
    zinc finger protein 846provided by RGD
    Primary source
    RGD:1564241
    See related
    EnsemblRapid:ENSRNOG00000020356 AllianceGenome:RGD:1564241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf426; Znf846; Zfp426l2; RGD1564241
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF846 (zinc finger protein 846). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 34.1), Lung (RPKM 33.6) and 9 other tissues See more
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    Genomic context

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    See Zfp846 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27395326..27413700)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19119788..19137120)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (21601021..21618389)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 266 Neighboring gene ribosomal protein SA, pseudogene 20 Neighboring gene uncharacterized LOC134480143 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene ubiquitin-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 426-like 2
    Names
    zinc finger protein 426

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134585.2 → NP_001128057.1  zinc finger protein 426-like 2

      See identical proteins and their annotated locations for NP_001128057.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNJ7
      Related
      ENSRNOP00000078184.2, ENSRNOT00000110234.2
      Conserved Domains (6) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:160 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162 → 184
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 52
      KRAB; KRAB box
      pfam13465
      Location:176 → 201
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27395326..27413700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265726.1 → XP_063121796.1  zinc finger protein 426-like 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ54

    2. XM_006242647.5 → XP_006242709.1  zinc finger protein 426-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006242709.1

      UniProtKB/TrEMBL
      A0A8I6AQ54
      Conserved Domains (6) summary
      smart00349
      Location:4 → 60
      KRAB; krueppel associated box
      COG5048
      Location:150 → 518
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:154 → 174
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:152 → 174
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4 → 42
      KRAB; KRAB box
      pfam13465
      Location:166 → 191
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063265727.1 → XP_063121797.1  zinc finger protein 426-like 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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