Flg filaggrin [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Flgprovided by RGD
Full Name: filaggrinprovided by RGD
Primary source: RGD:2620
See related: AllianceGenome:RGD:2620
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pflg
Summary: Predicted to enable keratin filament binding activity. Predicted to be a structural constituent of skin epidermis. Involved in epidermal cell differentiation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cornified envelope and keratohyalin granule. Human ortholog(s) of this gene implicated in atopic dermatitis 2 and ichthyosis vulgaris. Orthologous to human FLG (filaggrin). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Expression: Biased expression in Muscle (RPKM 11.0), Lung (RPKM 9.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (181583801..181596464)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (178884793..178912986)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (193565401..193574297)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The level of mRNA for differentiation markers: involucrin, filaggrin, keratinocyte differentiation associated protein and trichohyalin, was studied by RealTime PCR.
Title: Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation.
the filaggrin-histidine-urocanic acid pathway is not essential for stratum corneum acidification
Title: Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Flg (e-PCR), detects polymorphism
- UniSTS:518829

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables keratin filament binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info
enables structural constituent of skin epidermis	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
involved_in epidermis development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intermediate filament organization	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	TAS Traceable Author Statement more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in keratohyalin granule	ISO Inferred from Sequence Orthology more info
located_in keratohyalin granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: filaggrin

Names: Filaggrin (profilaggrin); profilaggrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393766.1 → NP_001380695.1 filaggrin

Status: VALIDATED

Source sequence(s)

JACYVU010000069

Conserved Domains (2) summary

PRK12678
Location:547 → 737

PRK12678; transcription termination factor Rho; Provisional

cd00213
Location:2 → 87

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...