Hnrnpk heterogeneous nuclear ribonucleoprotein K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hnrnpkprovided by RGD
Official Full Name: heterogeneous nuclear ribonucleoprotein Kprovided by RGD
Primary source: RGD:71058
See related: EnsemblRapid:ENSRNOG00000019113 AllianceGenome:RGD:71058
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Csbp; Hnrpk
Summary: Enables several functions, including ATPase binding activity; lamin binding activity; and nucleic acid binding activity. Involved in several processes, including gonad development; nervous system development; and regulation of gene expression. Located in axon terminus; cell cortex; and dendritic spine. Part of protein-DNA complex. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 1191.2), Lung (RPKM 946.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (6269302..6280429)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (6262936..6275001)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (6664730..6676753)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models.
Title: Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models.
results showed that hnRNP K was widely distributed in gonocytes, spermatogonia, sertoli cells and Leydig cells. The dynamic expression profile of hnRNP K may imply its crucial and potential roles in the development of the testis.
Title: Expression analysis of multifunctional RNA-binding protein hnRNP K during development of mammalian testis.
Results show that synaptic activity and BDNF regulate hnRNP K and hnRNP K-bound mRNAs in vitro and in vivo. The large number of transcripts showing a decreased coimmunoprecipitation with hnRNP K on stimulation with BDNF suggests a role for this RNP in the regulation of neuronal function in general and, in particular, in the BDNF-mediated plasticity events.
Title: The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.
hnRNP K regulates dendritic spine density and long-term potentiation in cultured hippocampal neurons from embryonic rats. hnRNP K knockdown prevents ERK cascade activation.
Title: Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons.
hnRNP-K is required for myelin basic protein synthesis.
Title: Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K.
These results suggest that transcription factor Hnrnpk is a key regulator for primordial follicle assembly and development, which provides a new potential therapeutic target to regulate ovarian function and treat ovarian disease.
Title: Hnrnpk, a protein differentially expressed in immature rat ovarian development, is required for normal primordial follicle assembly and development.
Decreased recruitment of hnRNP K protein to the mutated sequence causes the low expression of CYP2D2 mRNA in dark agouti rats.
Title: The importance of heterogeneous nuclear ribonucleoprotein K on cytochrome P450 2D2 gene regulation: its binding is reduced in Dark Agouti rats.
hnRNP K is a nuclear protein that binds to the insulin-responsive element of the rat angiotensinogen gene promoter and modulates angiotensinogen gene transcription in the kidney
Title: Heterogeneous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells.
In vitro a single kinase can phosphorylate K protein on multiple sites spanning the entire length of the protein, including residues contained within the RNA/DNA-binding domains.
Title: Casein kinases phosphorylate multiple residues spanning the entire hnRNP K length.
analysis of the hnRNP K protein-protein interactome
Title: Landscape of the hnRNP K protein-protein interactome.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables C-rich single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables actinin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA CDS binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA 3'-splice site binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoprotein complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in acute-phase response	IEP Inferred from Expression Pattern more info	PubMed
involved_in camera-type eye development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amino acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to rapamycin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IDA Inferred from Direct Assay more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of branching morphogenesis of a nerve	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of low-density lipoprotein receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in random inactivation of X chromosome	IEA Inferred from Electronic Annotation more info
involved_in random inactivation of X chromosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in regulation of low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt	IEP Inferred from Expression Pattern more info	PubMed
involved_in thymus development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in podosome	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein K

Names: dC stretch-binding protein; hnRNP K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057141.1 → NP_476482.1 heterogeneous nuclear ribonucleoprotein K

See identical proteins and their annotated locations for NP_476482.1

Status: PROVISIONAL

Source sequence(s)

D17711

UniProtKB/Swiss-Prot

P61980

UniProtKB/TrEMBL

A6KAK1, F8WG62

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

6269302..6280429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253554.5 → XP_006253616.1 heterogeneous nuclear ribonucleoprotein K isoform X2

See identical proteins and their annotated locations for XP_006253616.1

UniProtKB/Swiss-Prot

P61980

UniProtKB/TrEMBL

A6KAK1, F8WG62

Related

ENSRNOP00000080312.1, ENSRNOT00000107930.2

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
XM_039095312.2 → XP_038951240.1 heterogeneous nuclear ribonucleoprotein K isoform X1

UniProtKB/TrEMBL

F8WG62, Q5D059

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
XM_063276035.1 → XP_063132105.1 heterogeneous nuclear ribonucleoprotein K isoform X3

UniProtKB/TrEMBL

F8WG62
XM_063276036.1 → XP_063132106.1 heterogeneous nuclear ribonucleoprotein K isoform X4

UniProtKB/TrEMBL

F8WG62
XM_006253555.4 → XP_006253617.1 heterogeneous nuclear ribonucleoprotein K isoform X5

See identical proteins and their annotated locations for XP_006253617.1

UniProtKB/TrEMBL

F8WG62

Related

ENSRNOP00000025915.7, ENSRNOT00000025916.7

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:120 → 189

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:363 → 436

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
XM_017600445.3 → XP_017455934.1 heterogeneous nuclear ribonucleoprotein K isoform X6

UniProtKB/TrEMBL

A0A8L2QEP8, F8WG62

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:120 → 189

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:363 → 436

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
XM_006253553.4 → XP_006253615.1 heterogeneous nuclear ribonucleoprotein K isoform X1

See identical proteins and their annotated locations for XP_006253615.1

UniProtKB/TrEMBL

F8WG62, Q5D059

Related

ENSRNOP00000025980.7, ENSRNOT00000025980.9

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
XM_063276037.1 → XP_063132107.1 heterogeneous nuclear ribonucleoprotein K isoform X5

UniProtKB/TrEMBL

F8WG62
XM_039095314.2 → XP_038951242.1 heterogeneous nuclear ribonucleoprotein K isoform X1

UniProtKB/TrEMBL

F8WG62, Q5D059

Conserved Domains (4) summary

pfam08067
Location:4 → 43

ROKNT; ROKNT (NUC014) domain

cd22432
Location:42 → 105

KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22433
Location:144 → 213

KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

cd22434
Location:387 → 460

KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins