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    Ntn1 netrin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114523, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ntn1provided by RGD
    Official Full Name
    netrin 1provided by RGD
    Primary source
    RGD:619809
    See related
    EnsemblRapid:ENSRNOG00000003947 AllianceGenome:RGD:619809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    netrin-1
    Summary
    Involved in several processes, including positive regulation of axon extension; small GTPase-mediated signal transduction; and substrate-dependent cell migration, cell extension. Predicted to be located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Predicted to be active in basement membrane and glutamatergic synapse. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 137.9), Heart (RPKM 113.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ntn1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (53398852..53597595, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (52899933..53098591, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (54761925..54982072, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 52 Neighboring gene syntaxin 8 Neighboring gene uncharacterized LOC134480811 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 like 1 Neighboring gene phosphoinositide-3-kinase, regulatory subunit 5 Neighboring gene transfer RNA threonine (anticodon UGU) 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction PubMed 
    involved_in Ras protein signal transduction PubMed 
    involved_in animal organ morphogenesis  
    involved_in anterior/posterior axon guidance  
    acts_upstream_of_or_within anterior/posterior axon guidance  
    involved_in apoptotic process  
    acts_upstream_of_or_within axon guidance  
    involved_in axon guidance PubMed 
    acts_upstream_of_or_within axonogenesis  
    acts_upstream_of cell population proliferation  
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-cell adhesion  
    involved_in chemorepulsion of axon  
    involved_in chemorepulsion of axon  
    involved_in chemorepulsion of axon  
    involved_in dendrite development  
    involved_in glial cell proliferation  
    acts_upstream_of glial cell proliferation  
    involved_in inner ear morphogenesis  
    acts_upstream_of_or_within inner ear morphogenesis  
    acts_upstream_of_or_within mammary gland development  
    involved_in mammary gland duct morphogenesis  
    acts_upstream_of_or_within mammary gland duct morphogenesis  
    involved_in motor neuron axon guidance  
    involved_in motor neuron migration  
    acts_upstream_of_or_within motor neuron migration  
    involved_in negative regulation of axon extension  
    acts_upstream_of_or_within negative regulation of axon extension  
    acts_upstream_of_or_within neuron migration  
    involved_in nuclear migration  
    acts_upstream_of_or_within nuclear migration  
    involved_in positive regulation of axon extension PubMed 
    involved_in positive regulation of axon extension  
    acts_upstream_of_or_within positive regulation of axon extension  
    involved_in positive regulation of cell motility PubMed 
    involved_in positive regulation of glial cell proliferation  
    acts_upstream_of_or_within positive regulation of glial cell proliferation  
    acts_upstream_of_or_within regulation of cell migration  
    involved_in regulation of glial cell migration  
    acts_upstream_of_or_within regulation of glial cell migration  
    involved_in regulation of synapse assembly  
    involved_in regulation of synapse assembly  
    involved_in substrate-dependent cell migration, cell extension PubMed 
    involved_in tissue development  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    located_in actin cytoskeleton  
    is_active_in basement membrane  
    located_in basement membrane  
    located_in basement membrane  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in extracellular region  
    located_in extracellular region  
    located_in extracellular region  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in synapse  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053731.3NP_446183.2  netrin-1 precursor

      See identical proteins and their annotated locations for NP_446183.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q924Z9
      UniProtKB/TrEMBL
      F1LPC8
      Related
      ENSRNOP00000005255.4, ENSRNOT00000005255.5
      Conserved Domains (4) summary
      smart00136
      Location:46283
      LamNT; Laminin N-terminal domain (domain VI)
      cd00055
      Location:284329
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:487601
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
      pfam00053
      Location:404441
      Laminin_EGF; Laminin EGF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      53398852..53597595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246568.5XP_006246630.1  netrin-1 isoform X1

      See identical proteins and their annotated locations for XP_006246630.1

      UniProtKB/Swiss-Prot
      Q924Z9
      UniProtKB/TrEMBL
      F1LPC8
      Conserved Domains (4) summary
      smart00136
      Location:46283
      LamNT; Laminin N-terminal domain (domain VI)
      cd00055
      Location:284329
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:487601
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
      pfam00053
      Location:404441
      Laminin_EGF; Laminin EGF domain
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