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    Pgghg protein-glucosylgalactosylhydroxylysine glucosidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgghgprovided by RGD
    Official Full Name
    protein-glucosylgalactosylhydroxylysine glucosidaseprovided by RGD
    Primary source
    RGD:1306015
    See related
    EnsemblRapid:ENSRNOG00000014783 AllianceGenome:RGD:1306015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Athl1; RGD1306015
    Summary
    Predicted to enable protein-glucosylgalactosylhydroxylysine glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be active in cytosol. Orthologous to human PGGHG (protein-glucosylgalactosylhydroxylysine glucosidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 100.4), Thymus (RPKM 90.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgghg in Genome Data Viewer
    Location:
    1q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205467179..205474185)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196038276..196044561)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (213734198..213743233)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase, subunit VIIIb Neighboring gene NLR family, pyrin domain containing 6 Neighboring gene interferon induced transmembrane protein 5 Neighboring gene interferon induced transmembrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Catalytic site of human protein-glucosylgalactosylhydroxylysine glucosidase: Three crucial carboxyl residues were determined by cloning and site-directed mutagenesis. Hamazaki H, et al. Biochem Biophys Res Commun, 2016 Jan 15. PMID 26682924
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-glucosylgalactosylhydroxylysine glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glucosylgalactosylhydroxylysine glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acid trehalase-like protein 1; protein-glucosylgalactosylhydroxylysine glucosidase
    Names
    ATH1, acid trehalase-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432266.1 → NP_001419195.1  acid trehalase-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HXL9, D3ZY02

    2. NM_001432267.1 → NP_001419196.1  acid trehalase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HXM0

    RNA

    1. NR_197278.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    2. NR_197279.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205467179..205474185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230587.5 → XP_006230649.2  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1

      Related
      ENSRNOP00000020004.7, ENSRNOT00000020004.10
      Conserved Domains (2) summary
      COG1554
      Location:95 → 616
      ATH1; Trehalose and maltose hydrolase (possible phosphorylase) [Carbohydrate transport and metabolism]
      pfam03632
      Location:291 → 603
      Glyco_hydro_65m; Glycosyl hydrolase family 65 central catalytic domain

    2. XM_063279694.1 → XP_063135764.1  protein-glucosylgalactosylhydroxylysine glucosidase isoform X2

      UniProtKB/TrEMBL
      A6HXM0

    RNA

    1. XR_005494647.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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