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    Acss1 acyl-CoA synthetase short-chain family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296259, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acss1provided by RGD
    Official Full Name
    acyl-CoA synthetase short-chain family member 1provided by RGD
    Primary source
    RGD:1306246
    See related
    EnsemblRapid:ENSRNOG00000007102 AllianceGenome:RGD:1306246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acas2l
    Summary
    Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 458.5), Heart (RPKM 410.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Acss1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (159910809..159960748, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139450383..139500325, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146420346..146470293, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cystatin F Neighboring gene adipocyte plasma membrane associated protein Neighboring gene uncharacterized LOC102547396 Neighboring gene visual system homeobox 1 Neighboring gene uncharacterized LOC108350499 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP binding  
    enables ATP binding  
    enables acetate-CoA ligase activity  
    enables acetate-CoA ligase activity PubMed 
    enables acetate-CoA ligase activity  
    enables propionate-CoA ligase activity  
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    acetyl-coenzyme A synthetase 2-like, mitochondrial
    Names
    acetyl-Coenzyme A synthetase 2 (AMP forming)-like
    NP_001099994.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106524.1NP_001099994.1  acetyl-coenzyme A synthetase 2-like, mitochondrial

      See identical proteins and their annotated locations for NP_001099994.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474050
      UniProtKB/TrEMBL
      A6KHF6, D3ZZN3
      Related
      ENSRNOP00000009627.4, ENSRNOT00000009627.7
      Conserved Domains (2) summary
      cd05966
      Location:57660
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
      TIGR02188
      Location:45670
      Ac_CoA_lig_AcsA; acetate--CoA ligase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      159910809..159960748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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