Vil1 villin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vil1provided by RGD
Official Full Name: villin 1provided by RGD
Primary source: RGD:1307048
See related: EnsemblRapid:ENSRNOG00000015408 AllianceGenome:RGD:1307048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vil
Summary: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including actin cytoskeleton organization; regulation of actin filament organization; and regulation of cell morphogenesis. Predicted to be located in several cellular components, including brush border; filopodium tip; and ruffle. Predicted to be active in actin cytoskeleton; cytoplasm; and lamellipodium. Orthologous to human VIL1 (villin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 217.9) and Testes (RPKM 16.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (83440248..83467963)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (75991141..76018860)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (81689802..81717623)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Villin 1 is released in plasma during acute kidney injury and shows potential as an early marker for proximal tubular injury/necrosis.
Title: Plasmatic Villin 1 Is a Novel In Vivo Marker of Proximal Tubular Cell Injury During Renal Ischemia-Reperfusion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129981 (e-PCR)
- UniSTS:213269

D9Mco100 (e-PCR)
- UniSTS:532332

GDB:542905 (e-PCR)
- UniSTS:157572

RH133743 (e-PCR)
- UniSTS:217026

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament severing	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hepatocyte growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic actin-based contraction involved in cell motility	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in intestinal D-glucose absorption	ISO Inferred from Sequence Orthology more info
NOT involved_in microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus length	ISO Inferred from Sequence Orthology more info
involved_in regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in terminal web assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin filament bundle	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: villin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108224.2 → NP_001101694.1 villin-1

See identical proteins and their annotated locations for NP_001101694.1

Status: PROVISIONAL

Source sequence(s)

BC168981

UniProtKB/TrEMBL

A6JVU7, B5DFA0, F7F8Y1

Related

ENSRNOP00000021432.4, ENSRNOT00000021432.7

Conserved Domains (7) summary

cd11288
Location:513 → 603

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:136 → 225

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 121

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:619 → 715

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:250 → 348

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:392 → 492

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

pfam02209
Location:792 → 826

VHP; Villin headpiece domain