Lrrc19 leucine rich repeat containing 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc19provided by RGD
Official Full Name: leucine rich repeat containing 19provided by RGD
Primary source: RGD:1591722
See related: EnsemblRapid:ENSRNOG00000022225 AllianceGenome:RGD:1591722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including host-mediated regulation of intestinal microbiota composition; positive regulation of intracellular signal transduction; and regulation of defense response. Predicted to be active in plasma membrane. Orthologous to human LRRC19 (leucine rich repeat containing 19). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 706.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (114610625..114623682, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (109494891..109507948, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (113614164..113626834, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in host-mediated regulation of intestinal microbiota composition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109413.3 → NP_001102883.1 leucine-rich repeat-containing protein 19 precursor

See identical proteins and their annotated locations for NP_001102883.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JRG7, D4A6K7

Related

ENSRNOP00000038898.2, ENSRNOT00000037206.6

Conserved Domains (5) summary

smart00082
Location:173 → 210

LRRCT; Leucine rich repeat C-terminal domain

sd00031
Location:46 → 71

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:95 → 154

LRR_8; Leucine rich repeat

pfam15176
Location:245 → 359

LRR19-TM; Leucine-rich repeat family 19 TM domain

cd21340
Location:45 → 174

PPP1R42; protein phosphatase 1 regulatory subunit 42