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    Myorg myogenesis regulating glycosidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myorgprovided by RGD
    Official Full Name
    myogenesis regulating glycosidaseprovided by RGD
    Primary source
    RGD:1309821
    See related
    EnsemblRapid:ENSRNOG00000023208 AllianceGenome:RGD:1309821
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309821
    Summary
    Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in skeletal muscle fiber development. Predicted to act upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human MYORG (myogenesis regulating glycosidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 164.1), Liver (RPKM 89.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myorg in Genome Data Viewer
    Location:
    5q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61452956..61460500, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56654257..56664467, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (57873404..57882008, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 24 Neighboring gene nudix hydrolase 2 Neighboring gene uncharacterized LOC102553821 Neighboring gene sperm microtubule inner protein 6 Neighboring gene family with sequence similarity 219, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NET37, a nuclear envelope transmembrane protein with glycosidase homology, is involved in myoblast differentiation. Datta K, et al. J Biol Chem, 2009 Oct 23. PMID 19706595, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle fiber development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myogenesis-regulating glycosidase
    NP_001102441.1
    XP_006238156.1
    XP_063144178.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108971.1 → NP_001102441.1  myogenesis-regulating glycosidase

      See identical proteins and their annotated locations for NP_001102441.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6IIV2, D4AE63
      Conserved Domains (2) summary
      cd06592
      Location:313 → 684
      GH31_NET37; glucosidase NET37
      pfam01055
      Location:328 → 706
      Glyco_hydro_31; Glycosyl hydrolases family 31

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      61452956..61460500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288108.1 → XP_063144178.1  myogenesis-regulating glycosidase isoform X1

      UniProtKB/TrEMBL
      A6IIV2, D4AE63
      Related
      ENSRNOP00000093769.1, ENSRNOT00000098318.2

    2. XM_006238094.3 → XP_006238156.1  myogenesis-regulating glycosidase isoform X1

      See identical proteins and their annotated locations for XP_006238156.1

      UniProtKB/TrEMBL
      A6IIV2, D4AE63
      Related
      ENSRNOP00000033466.3, ENSRNOT00000033235.7
      Conserved Domains (2) summary
      cd06592
      Location:313 → 684
      GH31_NET37; glucosidase NET37
      pfam01055
      Location:328 → 706
      Glyco_hydro_31; Glycosyl hydrolases family 31
    Nucleotide Protein Strain
    Heading Accession and Version

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