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    Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pik3ap1provided by RGD
    Official Full Name
    phosphoinositide-3-kinase adaptor protein 1provided by RGD
    Primary source
    RGD:1307744
    See related
    EnsemblRapid:ENSRNOG00000013309 AllianceGenome:RGD:1307744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and signaling receptor binding activity. Predicted to be involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of inflammatory response; and regulation of innate immune response. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human PIK3AP1 (phosphoinositide-3-kinase adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 187.3), Liver (RPKM 100.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pik3ap1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (250040250..250194364, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (240090854..240245007, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (260527344..260679132, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100036 Neighboring gene tolloid-like 2 Neighboring gene transmembrane 9 superfamily member 3 Neighboring gene ligand dependent nuclear receptor corepressor Neighboring gene slit guidance ligand 1 Neighboring gene uncharacterized LOC134485238

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics. Matsumura T, et al. Biochem Biophys Res Commun, 2010 Sep 17. PMID 20728433
    2. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Ni M, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187458, Free PMC Article
    3. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Troutman TD, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187460, Free PMC Article
    4. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Okada T, et al. Immunity, 2000 Dec. PMID 11163197
    5. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol 3-kinase regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 9 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphoinositide 3-kinase adapter protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106368.3 → NP_001099838.1  phosphoinositide 3-kinase adapter protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001099838.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JH76, F1LXQ8
      Related
      ENSRNOP00000060785.4, ENSRNOT00000065632.5
      Conserved Domains (1) summary
      pfam14545
      Location:181 → 319
      DBB; Dof, BCAP, and BANK (DBB) motif,

    2. NM_001398791.2 → NP_001385720.1  phosphoinositide 3-kinase adapter protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      B5DFG9
      Related
      ENSRNOP00000017938.5, ENSRNOT00000017938.8
      Conserved Domains (2) summary
      pfam14545
      Location:181 → 319
      DBB; Dof, BCAP, and BANK (DBB) motif,
      pfam18567
      Location:11 → 142
      TIR_3; Toll/interleukin-1 receptor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      250040250..250194364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287325.1 → XP_063143395.1  phosphoinositide 3-kinase adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      F1M784

    2. XM_063287327.1 → XP_063143397.1  phosphoinositide 3-kinase adapter protein 1 isoform X2

      UniProtKB/TrEMBL
      B5DFG9

    3. XM_063287328.1 → XP_063143398.1  phosphoinositide 3-kinase adapter protein 1 isoform X3

    4. XM_063287330.1 → XP_063143400.1  phosphoinositide 3-kinase adapter protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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