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    Klf15 KLF transcription factor 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85497, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klf15provided by RGD
    Official Full Name
    KLF transcription factor 15provided by RGD
    Primary source
    RGD:70918
    See related
    EnsemblRapid:ENSRNOG00000017808 AllianceGenome:RGD:70918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in nuclear speck. Orthologous to human KLF15 (KLF transcription factor 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 109.6), Liver (RPKM 91.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Klf15 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124522652..124535613)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (122965718..122978403)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122364688..122377690)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486812 Neighboring gene ZXD family zinc finger C Neighboring gene cilia and flagella associated protein 100 Neighboring gene uncharacterized LOC134486813 Neighboring gene aldehyde dehydrogenase 1 family, member L1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC108619

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cardiac muscle hypertrophy in response to stress  
    involved_in cellular response to peptide PubMed 
    acts_upstream_of_or_within glial cell differentiation  
    acts_upstream_of_or_within intracellular glucose homeostasis  
    involved_in negative regulation of peptidyl-lysine acetylation  
    involved_in podocyte differentiation  
    acts_upstream_of_or_within positive regulation of D-glucose import  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of Wnt signaling pathway  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within response to insulin  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    Krueppel-like factor 15
    Names
    Kruppel-like factor 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053536.2NP_445988.2  Krueppel-like factor 15

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
      Conserved Domains (3) summary
      COG5189
      Location:318400
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd21580
      Location:3320
      KLF15_N; N-terminal domain of Kruppel-like factor 15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      124522652..124535613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108490.2XP_038964418.1  Krueppel-like factor 15 isoform X1

      UniProtKB/TrEMBL
      A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
      Conserved Domains (3) summary
      COG5189
      Location:318400
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd21580
      Location:3320
      KLF15_N; N-terminal domain of Kruppel-like factor 15
    2. XM_063286783.1XP_063142853.1  Krueppel-like factor 15 isoform X1

      UniProtKB/TrEMBL
      A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
      Related
      ENSRNOP00000024011.2, ENSRNOT00000024011.7
    3. XM_017592934.3XP_017448423.1  Krueppel-like factor 15 isoform X1

      UniProtKB/TrEMBL
      A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
      Conserved Domains (3) summary
      COG5189
      Location:318400
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd21580
      Location:3320
      KLF15_N; N-terminal domain of Kruppel-like factor 15
    4. XM_006236882.5XP_006236944.1  Krueppel-like factor 15 isoform X1

      See identical proteins and their annotated locations for XP_006236944.1

      UniProtKB/TrEMBL
      A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
      Conserved Domains (3) summary
      COG5189
      Location:318400
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd21580
      Location:3320
      KLF15_N; N-terminal domain of Kruppel-like factor 15
    5. XM_063286785.1XP_063142855.1  Krueppel-like factor 15 isoform X1

      UniProtKB/TrEMBL
      A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
    6. XM_006236884.5XP_006236946.1  Krueppel-like factor 15 isoform X1

      See identical proteins and their annotated locations for XP_006236946.1

      UniProtKB/TrEMBL
      A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
      Conserved Domains (3) summary
      COG5189
      Location:318400
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:322344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd21580
      Location:3320
      KLF15_N; N-terminal domain of Kruppel-like factor 15
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