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    Bace1 beta-secretase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29392, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bace1provided by RGD
    Official Full Name
    beta-secretase 1provided by RGD
    Primary source
    RGD:2191
    See related
    EnsemblRapid:ENSRNOG00000016847 AllianceGenome:RGD:2191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bace
    Summary
    Enables peptidase activity. Involved in several processes, including cellular response to amyloid-beta; detection of mechanical stimulus involved in sensory perception of pain; and prepulse inhibition. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Used to study dementia. Biomarker of Alzheimer's disease; sensory peripheral neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 222.4), Heart (RPKM 151.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Bace1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55038842..55061138)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46142060..46166268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50140092..50162388)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule-like 1 Neighboring gene centrosomal protein 164 Neighboring gene ring finger protein 214 Neighboring gene proprotein convertase subtilisin/kexin type 7 Neighboring gene transgelin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding  
    enables aspartic-type endopeptidase activity  
    enables aspartic-type endopeptidase activity  
    enables aspartic-type endopeptidase activity  
    enables endopeptidase activity  
    enables endopeptidase activity  
    enables enzyme binding  
    enables peptidase activity PubMed 
    enables peptidase activity  
    enables protein serine/threonine kinase binding  
    Process Evidence Code Pubs
    involved_in amyloid precursor protein catabolic process  
    involved_in amyloid-beta formation  
    involved_in amyloid-beta metabolic process  
    involved_in amyloid-beta metabolic process PubMed 
    acts_upstream_of_or_within amyloid-beta metabolic process  
    involved_in amyloid-beta metabolic process  
    acts_upstream_of_or_within amyloid-beta metabolic process  
    involved_in amyloid-beta metabolic process  
    involved_in cellular response to amyloid-beta PubMed 
    involved_in cellular response to copper ion PubMed 
    involved_in cellular response to manganese ion PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
    involved_in membrane protein ectodomain proteolysis  
    involved_in membrane protein ectodomain proteolysis  
    involved_in modulation of chemical synaptic transmission  
    involved_in positive regulation of neuron apoptotic process  
    involved_in prepulse inhibition PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in protein processing  
    involved_in proteolysis  
    acts_upstream_of_or_within proteolysis  
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in response to lead ion PubMed 
    involved_in signaling receptor ligand precursor processing  
    Items 1 - 20 of 44
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in axon PubMed 
    located_in axon  
    located_in axon  
    located_in cell surface  
    located_in cell surface  
    located_in cell surface  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle membrane  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in early endosome  
    located_in early endosome  
    located_in early endosome  
    located_in endoplasmic reticulum  
    is_active_in endosome  
    located_in endosome PubMed 
    located_in endosome  
    located_in endosome  
    is_active_in hippocampal mossy fiber to CA3 synapse  
    located_in late endosome  
    located_in late endosome  
    located_in late endosome  
    located_in lysosome  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in membrane raft  
    located_in multivesicular body  
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynapse  
    located_in recycling endosome  
    located_in recycling endosome  
    located_in recycling endosome  
    located_in synaptic vesicle PubMed 
    is_active_in trans-Golgi network  
    located_in trans-Golgi network  
    located_in trans-Golgi network  
    Items 1 - 20 of 44

    General protein information

    Preferred Names
    beta-secretase 1
    Names
    ASP2
    asp 2
    aspartyl protease 2
    beta-site APP cleaving enzyme 1
    beta-site amyloid precursor protein cleaving enzyme 1
    memapsin-2
    membrane-associated aspartic protease 2
    NP_062077.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019204.2NP_062077.1  beta-secretase 1 precursor

      See identical proteins and their annotated locations for NP_062077.1

      Status: VALIDATED

      Source sequence(s)
      AF190727, JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P56819
      UniProtKB/TrEMBL
      A0A8I6AHF6, A6J452, A6J453
      Related
      ENSRNOP00000022796.5, ENSRNOT00000022796.8
      Conserved Domains (1) summary
      cd05473
      Location:72437
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55038842..55061138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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