Gpd2 glycerol-3-phosphate dehydrogenase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpd2provided by RGD
Official Full Name: glycerol-3-phosphate dehydrogenase 2provided by RGD
Primary source: RGD:2726
See related: EnsemblRapid:ENSRNOG00000033824 AllianceGenome:RGD:2726
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mtGPDH
Summary: Predicted to enable glycerol-3-phosphate dehydrogenase (quinone) activity. Involved in NADH metabolic process and glycerol-3-phosphate metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 299.3), Adrenal (RPKM 206.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (62209432..62346590)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (41800552..41937729)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (43223892..43359069)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

By this approach, we also directly demonstrated that isolated mGPDH itself as well as its supramolecular assemblies are all capable of ROS production.
Title: ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase.
These results show that leptin downregulates mGPD activity, mainly when hyperleptinemia is chronic.
Title: Chronic leptin treatment inhibits liver mitochondrial alpha-glycerol-beta-phosphate dehydrogenase in euthyroid rats.
the up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS generation and may result in the progression of prostate cancer
Title: Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE109866 (e-PCR)
- UniSTS:248366

BM385025 (e-PCR)
- UniSTS:260930

RH142251 (e-PCR)
- UniSTS:231499

D3Chm72 (e-PCR)
- UniSTS:265372

AU026894 (e-PCR)
- UniSTS:113831

d3mgh21 (e-PCR)
- UniSTS:121782

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycerol-3-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophosphate shuttle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycerol-3-phosphate dehydrogenase, mitochondrial

Names: GPD-M; GPDH-M; Glycerol-3-phosophate dehydrogenase 2 (mitochondrial); glycerol-3-phosphate dehydrogenase 2, mitochondrial; mtGPDH gene, promoter region and alternative transcripts

NP_036868.1

EC 1.1.5.3

XP_038960257.1

EC 1.1.5.3

XP_038960258.1

EC 1.1.5.3

XP_038960259.1

EC 1.1.5.3

XP_038960262.1

EC 1.1.5.3

XP_038960263.1

EC 1.1.5.3

XP_063139207.1

EC 1.1.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012736.2 → NP_036868.1 glycerol-3-phosphate dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_036868.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P35571

UniProtKB/TrEMBL

F1LNI0

Related

ENSRNOP00000043749.6, ENSRNOT00000044419.6

Conserved Domains (2) summary

cd00051
Location:627 → 689

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl40741
Location:1 → 599

DAO; FAD dependent oxidoreductase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

62209432..62346590

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104331.2 → XP_038960259.1 glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

P35571

UniProtKB/TrEMBL

F1LNI0

Related

ENSRNOP00000071643.3, ENSRNOT00000090323.3

Conserved Domains (2) summary

cd00051
Location:627 → 689

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl40741
Location:1 → 599

DAO; FAD dependent oxidoreductase
XM_039104334.2 → XP_038960262.1 glycerol-3-phosphate dehydrogenase, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I5ZUG1, F1LNI0

Related

ENSRNOP00000082171.1, ENSRNOT00000110582.2

Conserved Domains (2) summary

cd00051
Location:627 → 689

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl40741
Location:1 → 599

DAO; FAD dependent oxidoreductase
XM_039104330.2 → XP_038960258.1 glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

P35571

UniProtKB/TrEMBL

F1LNI0

Conserved Domains (2) summary

cd00051
Location:627 → 689

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl40741
Location:1 → 599

DAO; FAD dependent oxidoreductase
XM_039104329.2 → XP_038960257.1 glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

P35571

UniProtKB/TrEMBL

F1LNI0

Conserved Domains (2) summary

cd00051
Location:627 → 689

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl40741
Location:1 → 599

DAO; FAD dependent oxidoreductase
XM_063283137.1 → XP_063139207.1 glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

P35571

UniProtKB/TrEMBL

F1LNI0
XM_039104335.2 → XP_038960263.1 glycerol-3-phosphate dehydrogenase, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A0G2K1F9, F1LNI0

Related

ENSRNOP00000071823.2, ENSRNOT00000088589.3

Conserved Domains (2) summary

cd00051
Location:600 → 662

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl40741
Location:23 → 572

DAO; FAD dependent oxidoreductase