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    Preb prolactin regulatory element binding [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58842, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prebprovided by RGD
    Official Full Name
    prolactin regulatory element bindingprovided by RGD
    Primary source
    RGD:61929
    See related
    EnsemblRapid:ENSRNOG00000007141 AllianceGenome:RGD:61929
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mSec12
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in COPII vesicle coating and positive regulation of transcription by RNA polymerase II. Is active in endoplasmic reticulum membrane. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 254.5), Muscle (RPKM 212.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Preb in Genome Data Viewer
    Location:
    6q14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31138757..31142544)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25418805..25422594)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26784088..26787875)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene transcription factor 23 Neighboring gene proline rich 30 Neighboring gene abhydrolase domain containing 1 Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene ketohexokinase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum exit site  
    is_active_in endoplasmic reticulum exit site  
    is_active_in endoplasmic reticulum exit site  
    is_active_in endoplasmic reticulum membrane  
    is_active_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    guanine nucleotide-exchange factor SEC12
    Names
    mammalian guanine nucleotide exchange factor Sec12
    mammalian guanine nucleotide exchange factor mSec12
    prolactin regulatory element-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170708.1NP_001164179.1  guanine nucleotide-exchange factor SEC12

      See identical proteins and their annotated locations for NP_001164179.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078936
      UniProtKB/Swiss-Prot
      Q6AYS1, Q9WTV0
      UniProtKB/TrEMBL
      A6HAA1, G3V6W2
      Related
      ENSRNOP00000009566.5, ENSRNOT00000009565.8
      Conserved Domains (3) summary
      COG2319
      Location:140354
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1667
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:159353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      31138757..31142544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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