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    Prl6a1 prolactin family 6, subfamily A, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24657, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prl6a1provided by RGD
    Official Full Name
    prolactin family 6, subfamily A, member 1provided by RGD
    Primary source
    RGD:3405
    See related
    EnsemblRapid:ENSRNOG00000017089 AllianceGenome:RGD:3405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plpb; Ghd13; Prlpb
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 3.4) See more
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    Genomic context

    See Prl6a1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (37883623..37888467, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (37675239..37680083, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (42705730..42710574, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene prolactin family 2, subfamily B, member 1 Neighboring gene prolactin family 8, subfamily A, member 2 Neighboring gene prolactin family 3, subfamily A, member 1 Neighboring gene prolactin family 3, subfamily B, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity  
    enables hormone activity  
    enables metal ion binding  
    enables prolactin receptor binding  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway  
    involved_in female pregnancy  
    involved_in mammary gland development  
    involved_in positive regulation of lactation  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT  
    involved_in response to nutrient levels  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  

    General protein information

    Preferred Names
    prolactin-6A1
    Names
    PLP-B
    PRL-like protein B
    growth hormone d13
    placental prolactin-like protein B
    prolactin-like protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022176.2NP_071512.2  prolactin-6A1 precursor

      See identical proteins and their annotated locations for NP_071512.2

      Status: VALIDATED

      Source sequence(s)
      BC158563
      UniProtKB/Swiss-Prot
      P24800, Q63439
      UniProtKB/TrEMBL
      A0A0M6L0M1, B0BMU3, F7EXQ2
      Related
      ENSRNOP00000022944.5, ENSRNOT00000022944.7
      Conserved Domains (1) summary
      pfam00103
      Location:37234
      Hormone_1; Somatotropin hormone family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      37883623..37888467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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