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    Fut2 fucosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58924, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fut2provided by RGD
    Official Full Name
    fucosyltransferase 2provided by RGD
    Primary source
    RGD:2639
    See related
    EnsemblRapid:ENSRNOG00000021011 AllianceGenome:RGD:2639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ftc; Futb
    Summary
    Enables galactoside 2-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Human ortholog(s) of this gene implicated in vitamin B12 deficiency. Orthologous to human FUT2 (fucosyltransferase 2 (H blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 11.6), Thymus (RPKM 10.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Fut2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105256013..105276828, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96119549..96139567, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101631633..101651668, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Ras interacting protein 1 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in fucosylation  
    involved_in fucosylation PubMed 
    involved_in fucosylation  
    involved_in fucosylation  
    involved_in glycolipid metabolic process  
    involved_in glycolipid metabolic process  
    involved_in glycolipid metabolic process  
    involved_in oligosaccharide biosynthetic process  
    involved_in oligosaccharide biosynthetic process  
    involved_in protein glycosylation  
    involved_in protein glycosylation  
    acts_upstream_of_or_within protein glycosylation  
    involved_in regulation of cell adhesion  
    involved_in regulation of endothelial cell proliferation  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane  

    General protein information

    Preferred Names
    galactoside alpha-(1,2)-fucosyltransferase 2
    Names
    GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
    alpha 1,2-fucosyltransferase B
    alpha 1-2 fucosyltransferase
    alpha 12-fucosyltransferase C
    alpha(1,2)FT 2
    alpha1,2-fucosyltransferase b
    fucosyltransferase 2 (secretor status included)
    galactoside 2-alpha-L-fucosyltransferase 2
    secretor blood group alpha-2-fucosyltransferase
    type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
    type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
    NP_113823.1
    XP_038944697.1
    XP_063128208.1
    XP_063128215.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031635.1NP_113823.1  galactoside alpha-(1,2)-fucosyltransferase 2

      See identical proteins and their annotated locations for NP_113823.1

      Status: PROVISIONAL

      Source sequence(s)
      AB006138
      UniProtKB/Swiss-Prot
      O35087, Q10984, Q9JK44, Q9R275
      UniProtKB/TrEMBL
      A0A0G2JSS7, A6JB65
      Related
      ENSRNOP00000028519.1, ENSRNOT00000028519.4
      Conserved Domains (1) summary
      pfam01531
      Location:52344
      Glyco_transf_11; Glycosyl transferase family 11

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105256013..105276828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272138.1XP_063128208.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      O35087, Q10984, Q9JK44, Q9R275
      UniProtKB/TrEMBL
      A0A0G2JSS7, A6JB65
      Related
      ENSRNOP00000093031.1, ENSRNOT00000097049.2
    2. XM_039088769.2XP_038944697.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      O35087, Q10984, Q9JK44, Q9R275
      UniProtKB/TrEMBL
      A0A0G2JSS7, A6JB65
      Related
      ENSRNOP00000081835.1, ENSRNOT00000099964.2
      Conserved Domains (1) summary
      pfam01531
      Location:52344
      Glyco_transf_11; Glycosyl transferase family 11
    3. XM_063272145.1XP_063128215.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      O35087, Q10984, Q9JK44, Q9R275
      UniProtKB/TrEMBL
      A0A0G2JSS7, A6JB65
      Related
      ENSRNOP00000091583.1, ENSRNOT00000101535.2
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