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    Rorb RAR-related orphan receptor B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309288, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rorbprovided by RGD
    Official Full Name
    RAR-related orphan receptor Bprovided by RGD
    Primary source
    RGD:1306778
    See related
    EnsemblRapid:ENSRNOG00000013413 AllianceGenome:RGD:1306778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in Brain (RPKM 50.4), Uterus (RPKM 19.7) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Rorb in Genome Data Viewer
    Location:
    1q51
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (225790216..225970973, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (216363629..216544390, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (234252757..234442597)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 40 Neighboring gene uncharacterized LOC102554711 Neighboring gene transient receptor potential cation channel, subfamily M, member 6 Neighboring gene uncharacterized LOC102554959 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 2 Neighboring gene uncharacterized LOC120098081

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables melatonin receptor activity  
    enables melatonin receptor activity PubMed 
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables zinc ion binding  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in amacrine cell differentiation  
    involved_in amacrine cell differentiation  
    involved_in cellular response to retinoic acid PubMed 
    involved_in circadian rhythm PubMed 
    involved_in eye photoreceptor cell development  
    involved_in eye photoreceptor cell development  
    involved_in intracellular receptor signaling pathway  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of osteoblast differentiation  
    involved_in negative regulation of osteoblast differentiation  
    involved_in negative regulation of osteoblast differentiation  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to hormone PubMed 
    involved_in retina development in camera-type eye  
    involved_in retina development in camera-type eye  
    involved_in retinal cone cell development  
    involved_in retinal cone cell development  
    involved_in retinal cone cell development  
    involved_in retinal rod cell development  
    involved_in retinal rod cell development  
    involved_in retinal rod cell development  
    acts_upstream_of_or_within retinal rod cell differentiation  
    involved_in visual perception  
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    nuclear receptor ROR-beta
    Names
    RAR-related orphan receptor beta
    nuclear receptor RZR-beta
    nuclear receptor subfamily 1 group F member 2
    retinoid-related orphan receptor-beta
    transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270958.1NP_001257887.1  nuclear receptor ROR-beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JX88, A0A8I5ZY30
      Related
      ENSRNOP00000070178.1, ENSRNOT00000091814.3
      Conserved Domains (2) summary
      cd06939
      Location:210450
      NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
      cd06968
      Location:397
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      225790216..225970973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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