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    B3gat3 beta-1,3-glucuronyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B3gat3provided by RGD
    Official Full Name
    beta-1,3-glucuronyltransferase 3provided by RGD
    Primary source
    RGD:1311968
    See related
    EnsemblRapid:ENSRNOG00000019873 AllianceGenome:RGD:1311968
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity and protein phosphatase activator activity. Predicted to be involved in several processes, including chondroitin sulfate proteoglycan biosynthetic process; glycosaminoglycan biosynthetic process; and positive regulation of intracellular protein transport. Predicted to act upstream of or within dermatan sulfate proteoglycan biosynthetic process and heparan sulfate proteoglycan biosynthetic process. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Larsen-like syndrome B3GAT3 type. Orthologous to human B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 367.5), Kidney (RPKM 180.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B3gat3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215246453..215253033)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205817374..205823928)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225120061..225126579)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551607 Neighboring gene integrator complex subunit 5 Neighboring gene glucosidase II alpha subunit Neighboring gene retinal outer segment membrane protein 1 Neighboring gene EMAP like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3. Budde BS, et al. Hum Genet, 2015 Jul. PMID 25893793
    2. Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair. Venkatesan N, et al. Proc Natl Acad Sci U S A, 2004 Dec 28. PMID 15601778, Free PMC Article
    3. Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. Baasanjav S, et al. Am J Hum Genet, 2011 Jul 15. PMID 21763480, Free PMC Article
    4. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. Koike T, et al. J Biol Chem, 2014 Mar 7. PMID 24425863, Free PMC Article
    5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GlcAT-I has a role in controlling and reversing articular cartilage defects
      Title: Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: a strategy to promote cartilage repair.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188078

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dermatan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dermatan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
    Names
    beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
    NP_001121656.1
    XP_038964511.1
    XP_063142988.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128184.1 → NP_001121656.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

      See identical proteins and their annotated locations for NP_001121656.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6AFX5, B2GV35, B5DEK9
      Related
      ENSRNOP00000105268.1, ENSRNOT00000173965.1
      Conserved Domains (1) summary
      cd00218
      Location:75 → 313
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215246453..215253033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108583.2 → XP_038964511.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X2

      Conserved Domains (1) summary
      cl11394
      Location:75 → 206
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_063286918.1 → XP_063142988.1  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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