Hexa hexosaminidase subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hexaprovided by RGD
Official Full Name: hexosaminidase subunit alphaprovided by RGD
Primary source: RGD:2792
See related: EnsemblRapid:ENSRNOG00000010252 AllianceGenome:RGD:2792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable acetylglucosaminyltransferase activity; beta-N-acetylhexosaminidase activity; and protein heterodimerization activity. Predicted to be involved in several processes, including N-glycan processing; ganglioside catabolic process; and glycosaminoglycan catabolic process. Predicted to act upstream of or within several processes, including adult walking behavior; nervous system development; and sensory perception of sound. Predicted to be located in azurophil granule and cytosol. Predicted to be part of beta-N-acetylhexosaminidase complex. Predicted to be active in lysosome and membrane. Human ortholog(s) of this gene implicated in Tay-Sachs disease. Orthologous to human HEXA (hexosaminidase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 753.1), Adrenal (RPKM 497.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (68832524..68857462)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (59936526..59961654)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (64325435..64350775)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

different regulatory factors are responsible for onset of Hex expression in these cell types during development.
Title: Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134318 (e-PCR)
- UniSTS:217600

Hexa (e-PCR), detects polymorphism
- UniSTS:508009

RH136740 (e-PCR)
- UniSTS:218829

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables beta-N-acetylglucosaminidase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylhexosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-N-acetylhexosaminidase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylhexosaminidase activity	ISO Inferred from Sequence Orthology more info
enables beta-N-acetylhexosaminidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate derivative metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in dermatan sulfate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ganglioside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ganglioside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ganglioside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ganglioside catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycosaminoglycan metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycosaminoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycosaminoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid storage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of location in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling posture	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sexual reproduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
part_of beta-N-acetylhexosaminidase complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-hexosaminidase subunit alpha

Names: Hexose aminidase A (alpha polypeptide); N-acetyl-beta-glucosaminidase subunit alpha; beta-N-acetylhexosaminidase subunit alpha; hexosaminidase A; hexosaminidase subunit A

NP_001004443.1

EC 3.2.1.52

XP_017451050.1

EC 3.2.1.52

XP_063121199.1

EC 3.2.1.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004443.1 → NP_001004443.1 beta-hexosaminidase subunit alpha precursor

See identical proteins and their annotated locations for NP_001004443.1

Status: PROVISIONAL

Source sequence(s)

BC082097

UniProtKB/Swiss-Prot

Q641X3

UniProtKB/TrEMBL

A0A8L2Q7B4, A6J526

Related

ENSRNOP00000013747.5, ENSRNOT00000013747.6

Conserved Domains (2) summary

cd06562
Location:167 → 510

GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...

pfam14845
Location:24 → 145

Glycohydro_20b2; beta-acetyl hexosaminidase like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

68832524..68857462

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265129.1 → XP_063121199.1 beta-hexosaminidase subunit alpha isoform X2
XM_017595561.3 → XP_017451050.1 beta-hexosaminidase subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8L2Q7B4