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    Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116457, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mapk8ip1provided by RGD
    Official Full Name
    mitogen-activated protein kinase 8 interacting protein 1provided by RGD
    Primary source
    RGD:70937
    See related
    EnsemblRapid:ENSRNOG00000058478 AllianceGenome:RGD:70937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    JIP1; Jip-1; Mapk8ip
    Summary
    Enables MAP-kinase scaffold activity; identical protein binding activity; and protein kinase binding activity. Involved in negative regulation of JUN kinase activity and negative regulation of apoptotic process. Located in axonal growth cone; dendritic growth cone; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 500.0), Kidney (RPKM 189.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Mapk8ip1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98810540..98829302, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (78355051..78372946, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (81295023..81304181, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene LARGE xylosyl- and glucuronyltransferase 2 Neighboring gene peroxisomal biogenesis factor 16 Neighboring gene Frey regulator of sperm-oocyte fusion 1 Neighboring gene cryptochrome circadian regulator 2 Neighboring gene uncharacterized LOC102546693 Neighboring gene solute carrier family 35 member C1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables JUN kinase binding  
    enables JUN kinase binding PubMed 
    enables MAP-kinase scaffold activity  
    enables MAP-kinase scaffold activity  
    enables MAP-kinase scaffold activity PubMed 
    enables MAP-kinase scaffold activity  
    enables identical protein binding PubMed 
    enables kinesin binding  
    enables kinesin binding  
    enables kinesin binding  
    enables mitogen-activated protein kinase kinase binding PubMed 
    enables mitogen-activated protein kinase kinase kinase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein kinase binding  
    Process Evidence Code Pubs
    involved_in JNK cascade  
    acts_upstream_of_or_within JUN phosphorylation  
    involved_in MAPK cascade  
    involved_in negative regulation of JNK cascade PubMed 
    involved_in negative regulation of JUN kinase activity PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade  
    involved_in regulation of CD8-positive, alpha-beta T cell proliferation  
    involved_in regulation of CD8-positive, alpha-beta T cell proliferation  
    involved_in regulation of CD8-positive, alpha-beta T cell proliferation  
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of JNK cascade  
    involved_in regulation of JNK cascade  
    acts_upstream_of_or_within signal transduction  
    involved_in vesicle-mediated transport  
    acts_upstream_of_or_within vesicle-mediated transport  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in axon  
    located_in axonal growth cone PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    located_in dendrite  
    located_in dendritic growth cone PubMed 
    located_in dentate gyrus mossy fiber  
    located_in dentate gyrus mossy fiber  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in mitochondrial membrane  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in synapse  
    located_in synapse  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    C-Jun-amino-terminal kinase-interacting protein 1
    Names
    IB-1
    JIP-1-related protein
    JNK MAP kinase scaffold protein 1
    JNK-interacting protein 1
    JRP
    islet-brain-1
    mitogen activated protein kinase 8 interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429682.1NP_001416611.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      B0VXR5, O88979, Q9R1H8, Q9R237, Q9WVI5, Q9WVI6
      UniProtKB/TrEMBL
      A0A8I6ABA5
    2. NM_001429683.1NP_001416612.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ABA5
    3. NM_001429684.1NP_001416613.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNG8, A6HNH0
    4. NM_053777.2NP_446229.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_446229.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ABA5, A6HNG9
      Related
      ENSRNOP00000074684.1, ENSRNOT00000079746.3
      Conserved Domains (2) summary
      cd11943
      Location:480534
      SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
      cd01212
      Location:551699
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      98810540..98829302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104100.2XP_038960028.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform X2

      Conserved Domains (3) summary
      cd11943
      Location:464518
      SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
      PHA03247
      Location:161332
      PHA03247; large tegument protein UL36; Provisional
      cd01212
      Location:535683
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
    2. XM_039104102.2XP_038960030.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1

      Related
      ENSRNOP00000089891.1, ENSRNOT00000111802.2
      Conserved Domains (3) summary
      cd11943
      Location:489543
      SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
      PHA03247
      Location:186357
      PHA03247; large tegument protein UL36; Provisional
      cd01212
      Location:560708
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
    3. XM_039104101.2XP_038960029.1  C-Jun-amino-terminal kinase-interacting protein 1 isoform X3

      Conserved Domains (4) summary
      cd11943
      Location:455509
      SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
      PHA03247
      Location:152323
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:60437
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01212
      Location:526674
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
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