Obp1f odorant binding protein I f [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Obp1fprovided by RGD
Full Name: odorant binding protein I fprovided by RGD
Primary source: RGD:621639
See related: EnsemblRapid:ENSRNOG00000086793 AllianceGenome:RGD:621639
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Obp-1f
Summary: Enables odorant binding activity. Predicted to be involved in sensory perception of smell. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 4.2), Liver (RPKM 2.7) and 7 other tissues See more
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Genomic context

Location:: Xq21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (45833861..45839070)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (41955618..41960681)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (83847944..83864150, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

measured the effect of odorant-binding protein 1 on the rates of ligand uptake and liquid-to-air transfer rates with a set of defined odorous compounds
Title: Rapid odorant release in mammalian odour binding proteins facilitates their temporal coupling to odorant signals.
Results identify a novel population of odorant-binding protein-1f-secreting cells displaying morphological and functional characteristics similar to those of epithelial mucous cells.
Title: Leptin-sensitive OBP-expressing mucous cells in rat olfactory epithelium: a novel target for olfaction-nutrition crosstalk?
Comparisons are made between this 1.6A resolution structure and a modelled OBP1 structure based on aphrodisin, and with OPB2 and OBP3. It is monomeric.
Title: Structure of rat odorant-binding protein OBP1 at 1.6 A resolution.
The fine transcriptional control of OBP-1F in the olfactory mucosa following food deprivation could be efficient only at the local level, close to its site of secretion to participate in the perireceptor events of the olfactory signal reception.
Title: Transcription profile analysis reveals that OBP-1F mRNA is downregulated in the olfactory mucosa following food deprivation.
A three-dimensional structure of OBP-1F, modelled using the known structure of aphrodisin as template, allowed us to suggest the location of the observed structural changes outside of the binding pocket.
Title: Odorant binding and conformational changes of a rat odorant-binding protein.
Lipocalin strand pair opening in the presence of ligand is observed, consistent with potential role in olfactive receptor recognition.
Title: Odorant binding and conformational dynamics in the odorant-binding protein.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables odorant binding	IDA Inferred from Direct Assay more info	PubMed
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: odorant-binding protein

Names: OBP; odorant-binding protein 1F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138903.2 → NP_620258.2 odorant-binding protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K124, A6IPT5, A6IPT6, Q9QYU9

Related

ENSRNOP00000064887.2, ENSRNOT00000073734.3

Conserved Domains (1) summary

cd19427
Location:25 → 171

lipocalin_OBP-like; Lipocalin odorant-binding protein and similar proteins