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    Tatdn3 TatD DNase domain containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289378, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tatdn3provided by RGD
    Official Full Name
    TatD DNase domain containing 3provided by RGD
    Primary source
    RGD:1589779
    See related
    EnsemblRapid:ENSRNOG00000046460 AllianceGenome:RGD:1589779
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds and metal ion binding activity. Predicted to be located in mitochondrion. Orthologous to human TATDN3 (TatD DNase domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 67.3), Muscle (RPKM 44.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tatdn3 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105165384..105180167, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102634254..102649069, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109655292..109669573, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene FLVCR choline and heme transporter 1 Neighboring gene spermatogenesis associated 45 Neighboring gene NSL1 component of MIS12 kinetochore complex Neighboring gene uncharacterized LOC120096350 Neighboring gene basic leucine zipper ATF-like transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative deoxyribonuclease TATDN3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105987.1 → NP_001099457.1  putative deoxyribonuclease TATDN3

      See identical proteins and their annotated locations for NP_001099457.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A6JGY3, M0R5U3
      Related
      ENSRNOP00000064772.4, ENSRNOT00000073327.4
      Conserved Domains (1) summary
      cd01310
      Location:5 → 262
      TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105165384..105180167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090602.2 → XP_038946530.2  putative deoxyribonuclease TATDN3 isoform X5

      UniProtKB/TrEMBL
      M0R5U3

    2. XM_039090601.2 → XP_038946529.2  putative deoxyribonuclease TATDN3 isoform X4

      UniProtKB/TrEMBL
      M0R5U3

    3. XM_039090600.2 → XP_038946528.2  putative deoxyribonuclease TATDN3 isoform X3

      UniProtKB/TrEMBL
      M0R5U3

    4. XM_039090599.2 → XP_038946527.2  putative deoxyribonuclease TATDN3 isoform X2

      UniProtKB/TrEMBL
      M0R5U3

    5. XM_039090598.2 → XP_038946526.2  putative deoxyribonuclease TATDN3 isoform X1

      UniProtKB/TrEMBL
      M0R5U3
      Related
      ENSRNOP00000107959.1, ENSRNOT00000173931.1

    6. XM_063272188.1 → XP_063128258.1  putative deoxyribonuclease TATDN3 isoform X6

    7. XM_063272190.1 → XP_063128260.1  putative deoxyribonuclease TATDN3 isoform X8

    8. XM_039090604.2 → XP_038946532.1  putative deoxyribonuclease TATDN3 isoform X6

      Conserved Domains (1) summary
      pfam01026
      Location:19 → 199
      TatD_DNase; TatD related DNase

    9. XM_063272189.1 → XP_063128259.1  putative deoxyribonuclease TATDN3 isoform X8

    10. XM_039090605.2 → XP_038946533.1  putative deoxyribonuclease TATDN3 isoform X7

      Conserved Domains (1) summary
      cl00281
      Location:50 → 114
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    RNA

    1. XR_005492231.2 RNA Sequence

    2. XR_010056912.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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