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    Paqr8 progestin and adipoQ receptor family member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paqr8provided by RGD
    Official Full Name
    progestin and adipoQ receptor family member 8provided by RGD
    Primary source
    RGD:1311710
    See related
    EnsemblRapid:ENSRNOG00000067120 AllianceGenome:RGD:1311710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pmrbeta; RGD1311710
    Summary
    Predicted to enable nuclear steroid receptor activity and steroid binding activity. Predicted to be involved in response to steroid hormone. Predicted to be located in Golgi apparatus. Predicted to be active in plasma membrane. Orthologous to human PAQR8 (progestin and adipoQ receptor family member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 238.9), Testes (RPKM 92.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Paqr8 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (30808921..30858599)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (23312521..23362175)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (27005270..27054591)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480351 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102549795 Neighboring gene EF-hand domain containing 1 Neighboring gene translocation associated membrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus. Hornung RS, et al. Mol Pain, 2023 Jan-Dec. PMID 37699860, Free PMC Article
    2. Expression and regulation of progestin membrane receptors in the rat corpus luteum. Cai Z, et al. Endocrinology, 2005 Dec. PMID 16123161
    3. Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain. Intlekofer KA, et al. Neuroscience, 2011 Jan 13. PMID 20977928, Free PMC Article
    4. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus.
      Title: PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus.
    2. Expression patterns of Paqr8 is low and homogeneous in the hypothalamus and more abundant in thalamic nuclei, and is likely to regulate sensory and cognitive functions in forebrain tissues of female rats.
      Title: Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear steroid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to steroid hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor beta
    Names
    progestin and adipoQ receptor family member VIII
    progestin membrane receptor beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014099.2 → NP_001014121.1  membrane progestin receptor beta

      See identical proteins and their annotated locations for NP_001014121.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03
      Related
      ENSRNOP00000094604.1, ENSRNOT00000107820.2
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    2. NM_001432946.1 → NP_001419875.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    3. NM_001432947.1 → NP_001419876.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    4. NM_001432950.1 → NP_001419879.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    5. NM_001432951.1 → NP_001419880.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    6. NM_001432952.1 → NP_001419881.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    7. NM_001432953.1 → NP_001419882.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    8. NM_001432954.1 → NP_001419883.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    9. NM_001432955.1 → NP_001419884.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    10. NM_001432956.1 → NP_001419885.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    11. NM_001432957.1 → NP_001419886.1  membrane progestin receptor beta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      30808921..30858599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267116.1 → XP_063123186.1  membrane progestin receptor beta isoform X1

    2. XM_017596433.3 → XP_017451922.1  membrane progestin receptor beta isoform X1

      Related
      ENSRNOP00000086728.1, ENSRNOT00000107525.2
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    3. XM_039083548.2 → XP_038939476.1  membrane progestin receptor beta isoform X1

      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    4. XM_063267123.1 → XP_063123193.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    5. XM_063267124.1 → XP_063123194.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    6. XM_063267118.1 → XP_063123188.1  membrane progestin receptor beta isoform X1

    7. XM_063267120.1 → XP_063123190.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03
      Related
      ENSRNOP00000076707.1, ENSRNOT00000100549.2

    8. XM_063267117.1 → XP_063123187.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    9. XM_017596434.3 → XP_017451923.1  membrane progestin receptor beta isoform X1

      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    10. XM_039083545.2 → XP_038939473.1  membrane progestin receptor beta isoform X1

      Related
      ENSRNOP00000108197.1, ENSRNOT00000170502.1
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    11. XM_063267125.1 → XP_063123195.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    12. XM_017596435.3 → XP_017451924.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    13. XM_039083547.2 → XP_038939475.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03
      Related
      ENSRNOP00000105678.1, ENSRNOT00000124363.1
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related

    14. XM_063267127.1 → XP_063123197.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    15. XM_063267119.1 → XP_063123189.1  membrane progestin receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVB9, Q6AY03

    16. XM_063267122.1 → XP_063123192.1  membrane progestin receptor beta isoform X1

    17. XM_063267126.1 → XP_063123196.1  membrane progestin receptor beta isoform X1

    18. XM_039083546.2 → XP_038939474.1  membrane progestin receptor beta isoform X1

      Related
      ENSRNOP00000084979.1, ENSRNOT00000114681.2
      Conserved Domains (1) summary
      pfam03006
      Location:70 → 297
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version

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