U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Fzd2 frizzled class receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64512, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fzd2provided by RGD
    Official Full Name
    frizzled class receptor 2provided by RGD
    Primary source
    RGD:71012
    See related
    EnsemblRapid:ENSRNOG00000021962 AllianceGenome:RGD:71012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fz-10; Fzd10
    Summary
    Enables Wnt receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fzd2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88061988..88063898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87561866..87563776)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90550147..90552057)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC102550111 Neighboring gene ATPase H+ transporting V0 subunit C, pseudogene 1 Neighboring gene meiosis specific with coiled-coil domain

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables PDZ domain binding  
    enables PDZ domain binding  
    enables Wnt receptor activity  
    enables Wnt receptor activity PubMed 
    enables Wnt receptor activity  
    enables Wnt receptor activity  
    enables Wnt-protein binding  
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger PubMed 
    involved_in Wnt signaling pathway  
    involved_in Wnt signaling pathway, calcium modulating pathway PubMed 
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in cell-cell signaling  
    acts_upstream_of_or_within cell-cell signaling  
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to peptide hormone stimulus PubMed 
    involved_in cellular response to vitamin D PubMed 
    involved_in cochlea morphogenesis  
    acts_upstream_of_or_within cochlea morphogenesis  
    involved_in endothelial cell differentiation  
    acts_upstream_of_or_within endothelial cell differentiation  
    involved_in hard palate development  
    acts_upstream_of_or_within hard palate development  
    involved_in inner ear receptor cell development  
    acts_upstream_of_or_within inner ear receptor cell development  
    involved_in membranous septum morphogenesis  
    acts_upstream_of_or_within membranous septum morphogenesis  
    involved_in muscular septum morphogenesis  
    acts_upstream_of_or_within muscular septum morphogenesis  
    involved_in non-canonical Wnt signaling pathway  
    involved_in outflow tract morphogenesis  
    acts_upstream_of_or_within outflow tract morphogenesis  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in sensory perception of smell  
    acts_upstream_of_or_within sensory perception of smell  
    acts_upstream_of_or_within ventricular septum morphogenesis  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    frizzled-2
    Names
    Drosophila polarity gene (frizzled) homologue
    Drosophila polarity gene homolog 2
    frizzled family receptor 2
    fz-2
    rFz2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172035.2NP_742032.2  frizzled-2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q08464
      UniProtKB/TrEMBL
      A6HJL6, G3V954
      Related
      ENSRNOP00000112818.1, ENSRNOT00000145471.1
      Conserved Domains (2) summary
      cd07464
      Location:40166
      CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
      cd15245
      Location:239568
      7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88061988..88063898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.