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    Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287931, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppm1fprovided by RGD
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent, 1Fprovided by RGD
    Primary source
    RGD:631363
    See related
    EnsemblRapid:ENSRNOG00000037909 AllianceGenome:RGD:631363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CaMKPase
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and protein dephosphorylation. Located in cytosol and perinuclear region of cytoplasm. Orthologous to human PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 318.0), Lung (RPKM 192.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppm1f in Genome Data Viewer
    Location:
    11q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97568627..97598613, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (84064422..84094410, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (88313709..88343726, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene yippee-like 1 Neighboring gene mitogen activated protein kinase 1 Neighboring gene DNA topoisomerase III beta Neighboring gene V-set pre-B cell surrogate light chain 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables metal ion binding  
    enables myosin phosphatase activity  
    enables phosphoprotein phosphatase activity PubMed 
    enables protein serine/threonine phosphatase activity PubMed 
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    enables protein tyrosine/serine/threonine phosphatase activity  
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in cellular response to xenobiotic stimulus  
    involved_in cellular response to xenobiotic stimulus  
    involved_in chromatin remodeling  
    involved_in intrinsic apoptotic signaling pathway  
    involved_in intrinsic apoptotic signaling pathway  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin  
    involved_in negative regulation of peptidyl-serine phosphorylation  
    involved_in negative regulation of peptidyl-serine phosphorylation  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation  
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation  
    involved_in negative regulation of protein transport  
    involved_in peptidyl-serine dephosphorylation  
    involved_in peptidyl-threonine dephosphorylation  
    involved_in peptidyl-threonine dephosphorylation  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of chemotaxis  
    involved_in positive regulation of chemotaxis  
    involved_in positive regulation of cysteine-type endopeptidase activity PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of epithelial cell migration  
    involved_in positive regulation of epithelial cell migration  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of growth  
    involved_in positive regulation of growth  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in protein dephosphorylation PubMed 
    involved_in regulation of protein localization  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in signal transduction  
    Items 1 - 25 of 39
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    protein phosphatase 1F
    Names
    CaM-kinase phosphatase
    ca(2+)/calmodulin-dependent protein kinase phosphatase
    calcium/calmodulin-dependent protein kinase phosphatase
    partner of PIX 2
    protein phosphatase 1F (PP2C domain containing)
    NP_786931.1
    XP_006248736.1
    XP_038943992.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175755.2NP_786931.1  protein phosphatase 1F

      See identical proteins and their annotated locations for NP_786931.1

      Status: PROVISIONAL

      Source sequence(s)
      AB023634
      UniProtKB/Swiss-Prot
      Q9WVR7
      UniProtKB/TrEMBL
      A0A8I6A062, B2RYP5
      Conserved Domains (1) summary
      pfam00481
      Location:151402
      PP2C; Protein phosphatase 2C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      97568627..97598613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088064.2XP_038943992.1  protein phosphatase 1F isoform X1

      UniProtKB/Swiss-Prot
      Q9WVR7
      UniProtKB/TrEMBL
      A0A8I6A062, B2RYP5
      Conserved Domains (1) summary
      pfam00481
      Location:151402
      PP2C; Protein phosphatase 2C
    2. XM_006248674.4XP_006248736.1  protein phosphatase 1F isoform X1

      See identical proteins and their annotated locations for XP_006248736.1

      UniProtKB/Swiss-Prot
      Q9WVR7
      UniProtKB/TrEMBL
      A0A8I6A062, B2RYP5
      Related
      ENSRNOP00000002530.3, ENSRNOT00000002530.7
      Conserved Domains (1) summary
      pfam00481
      Location:151402
      PP2C; Protein phosphatase 2C
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