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    Psmb2 proteasome 20S subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29675, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmb2provided by RGD
    Official Full Name
    proteasome 20S subunit beta 2provided by RGD
    Primary source
    RGD:61874
    See related
    EnsemblRapid:ENSRNOG00000011463 AllianceGenome:RGD:61874
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in response to organic cyclic compound. Predicted to be located in nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 483.6), Adrenal (RPKM 466.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Psmb2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (144255058..144287200)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138970564..139002715)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144702004..144734220)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene atherin-like Neighboring gene claspin Neighboring gene similar to human chromosome 1 open reading frame 216 Neighboring gene uncharacterized LOC120102980 Neighboring gene transcription factor AP-2 epsilon Neighboring gene neurochondrin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  
    part_of proteasome complex  
    part_of proteasome core complex  
    part_of proteasome core complex  
    part_of proteasome core complex, beta-subunit complex  
    part_of proteasome core complex, beta-subunit complex  

    General protein information

    Preferred Names
    proteasome subunit beta type-2
    Names
    beta-4
    macropain subunit C7-I
    multicatalytic endopeptidase complex subunit C7-I
    proteasome (prosome, macropain) subunit, beta type 2
    proteasome beta 2 subunit
    proteasome component C7-I
    proteasome subunit beta 2
    proteasome subunit beta-4
    NP_058980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017284.1NP_058980.1  proteasome subunit beta type-2

      See identical proteins and their annotated locations for NP_058980.1

      Status: PROVISIONAL

      Source sequence(s)
      D21799
      UniProtKB/Swiss-Prot
      P40307
      UniProtKB/TrEMBL
      A6ISB2
      Related
      ENSRNOP00000015618.3, ENSRNOT00000015618.8
      Conserved Domains (1) summary
      cd03758
      Location:1192
      proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      144255058..144287200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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