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    Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnrnpul1provided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein U-like 1provided by RGD
    Primary source
    RGD:1307456
    See related
    EnsemblRapid:ENSRNOG00000020683 AllianceGenome:RGD:1307456
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpul1
    Summary
    Predicted to enable RNA binding activity and enzyme binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nucleus and synapse. Orthologous to human HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 403.0), Spleen (RPKM 309.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpul1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (90356182..90391923, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81228404..81264121, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82512745..82548446, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transforming growth factor, beta 1 Neighboring gene coiled-coil domain containing 97 Neighboring gene Axl receptor tyrosine kinase Neighboring gene uncharacterized LOC120096893

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. Kzhyshkowska J, et al. Biochem J, 2001 Sep 1. PMID 11513728, Free PMC Article
    2. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. Choe EA, et al. J Neurosci, 2007 Aug 29. PMID 17728463, Free PMC Article
    3. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein U-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108477.1 → NP_001101947.1  heterogeneous nuclear ribonucleoprotein U-like protein 1

      See identical proteins and their annotated locations for NP_001101947.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A6J988
      Conserved Domains (4) summary
      smart00513
      Location:3 → 37
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:424 → 569
      AAA_33; AAA domain
      cd12884
      Location:212 → 389
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:424 → 562
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      90356182..90391923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081811.2 → XP_038937739.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

      Conserved Domains (2) summary
      cd12884
      Location:112 → 289
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:324 → 469
      AAA_33; AAA domain

    2. XM_008758957.4 → XP_008757179.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_008757179.1

      Conserved Domains (3) summary
      pfam13671
      Location:325 → 470
      AAA_33; AAA domain
      cd12884
      Location:113 → 290
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:325 → 463
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. XM_008758955.3 → XP_008757177.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

      UniProtKB/TrEMBL
      D4A962
      Related
      ENSRNOP00000028100.5, ENSRNOT00000028100.9
      Conserved Domains (4) summary
      smart00513
      Location:3 → 37
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:425 → 570
      AAA_33; AAA domain
      cd12884
      Location:213 → 390
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:425 → 563
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    4. XM_039081808.2 → XP_038937736.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

      Conserved Domains (2) summary
      cd12884
      Location:112 → 289
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:324 → 469
      AAA_33; AAA domain

    5. XM_008758956.3 → XP_008757178.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_008757178.1

      Conserved Domains (3) summary
      pfam13671
      Location:325 → 470
      AAA_33; AAA domain
      cd12884
      Location:113 → 290
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:325 → 463
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein Strain
    Heading Accession and Version

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